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Mouse Anti-FABP2 Antibody (6BA3) (CBMAB-1215CQ)

This product is a mouse antibody that recognizes FABP2. The antibody 6BA3 can be used for immunoassay techniques such as: ELISA, WB.
See all FABP2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
6BA3
Antibody Isotype
IgG1
Application
ELISA, WB

Basic Information

Immunogen
Recombinant full length protein
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Fatty Acid Binding Protein 2
Introduction
The protein encoded by this gene is an intracellular fatty acid-binding protein that participates in the uptake, intracellular metabolism, and transport of long-chain fatty acids. FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.
Entrez Gene ID
UniProt ID
Alternative Names
Fatty Acid Binding Protein 2; Fatty Acid Binding Protein 2; Intestinal; Intestinal-Type Fatty Acid-Binding Protein; Fatty Acid-Binding Protein 2; I-FABP; FABPI
Research Area
FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.
Biological Process
Intestinal lipid absorption Source: GO_Central
Cellular Location
Cytoplasm

Maculewicz, E., Leońska-Duniec, A., Mastalerz, A., Szarska, E., Garbacz, A., Lepionka, T., ... & Bertrandt, J. (2022). The Influence of FTO, FABP2, LEP, LEPR, and MC4R Genes on Obesity Parameters in Physically Active Caucasian Men. International Journal of Environmental Research and Public Health, 19(10), 6030.

Leońska-Duniec, A., Świtała, K., Ahmetov, I. I., Pickering, C., Massidda, M., Buryta, M., ... & Maculewicz, E. (2021). FABP2 Ala54Thr polymorphism and post-training changes of body composition and biochemical parameters in Caucasian women. Genes, 12(7), 954.

Chen, X., Gao, Y., Wu, G., Gu, J., Cai, Y., Xu, J., & Cheng, H. (2020). Molecular cloning, tissue expression, and transcriptional regulation of fabp1 and fabp2 in javelin goby (Synechogobius hasta) in response to starvation stress. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 250, 110484.

Tsai, I. T., Wu, C. C., Hung, W. C., Lee, T. L., Hsuan, C. F., Wei, C. T., ... & Wang, C. P. (2020). FABP1 and FABP2 as markers of diabetic nephropathy. International journal of medical sciences, 17(15), 2338.

Zhao, Y., Cao, X., Fu, L., & Gao, J. (2020). n-3 PUFA reduction caused by fabp2 deletion interferes with triacylglycerol metabolism and cholesterolhomeostasis in fish. Applied microbiology and biotechnology, 104(5), 2149-2161.

Mel’nikova, E. S., Rymar, O. D., Ivanova, A. A., Mustafina, S. V., Shapkina, M. J., Bobak, M., ... & Maksimov, V. N. (2020). Association of polymorphisms of genes TCF7L2, FABP2, KCNQ1, ADIPOQ with the prognosis of the development of type 2 diabetes mellitus. Terapevticheskii arkhiv, 92(10), 40-47.

Han, T. K., & So, W. Y. (2019). Effects of FABP2 Ala54Thr gene polymorphism on obesity and metabolic syndrome in middle-aged Korean women with abdominal obesity. Central European journal of public health, 27(1), 37-43.

Liu, P. J., Liu, Y. P., Qin, H. K., Xing, T., Li, S. S., & Bao, Y. Y. (2019). Effects of polymorphism in FABP2 Ala54Thr on serum lipids and glycemic control in low glycemic index diets are associated with gender among Han Chinese with type 2 diabetes mellitus. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 12, 413.

Kops, N. L., Vivan, M. A., Horvath, J. D., de Castro, M. L., & Friedman, R. (2018). FABP2, LEPR223, LEP656, and FTO polymorphisms: effect on weight loss 2 years after bariatric surgery. Obesity Surgery, 28(9), 2705-2711.

Stevens, B. R., Goel, R., Seungbum, K., Richards, E. M., Holbert, R. C., Pepine, C. J., & Raizada, M. K. (2018). Increased human intestinal barrier permeability plasma biomarkers zonulin and FABP2 correlated with plasma LPS and altered gut microbiome in anxiety or depression. Gut, 67(8), 1555-1557.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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