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Rat Anti-FAM19A5 Recombinant Antibody (CBYJT-1278) (CBMAB-T0293-YJ)

Provided herein is a Rat monoclonal antibody, which binds to FAM19A5 (Family With Sequence Similarity 19 Member A5, C-C Motif Chemokine Like). The antibody can be used for immunoassay techniques, such as WB, IHC.
See all FAM19A5 antibodies

Summary

Host Animal
Rat
Specificity
Human
Clone
CBYJT-1278
Antibody Isotype
IgG1
Application
WB, IHC

Basic Information

Immunogen
E. coli-derived recombinant human TAFA5/FAM19A5, Gln26-Ser125, Accession # NP_056196
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, Trehalose
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 26-125

Target

Full Name
Family With Sequence Similarity 19 Member A5, C-C Motif Chemokine Like
Introduction
FAM19A5 is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to play a role as brain-specific chemokines or neurokines that act as regulators of immune and nervous cells.
Entrez Gene ID
25817
UniProt ID
Q7Z5A7
Alternative Names
Family With Sequence Similarity 19 Member A5, C-C Motif Chemokine Like; Family With Sequence Similarity 19 (Chemokine (C-C Motif)-Like), Member A5; Chemokine-Like Protein TAFA-5; TAFA5; Protein FAM19A5; TAFA Protein 5; QLLK5208; UNQ5208; TAFA-5
Research Area
Acts as a chemokine-like protein by regulating cell proliferation and migration through activation of G protein-coupled receptors (GPCRs), such as S1PR2 and FPR2 (By similarity).

Stimulates chemotactic migration of macrophages mediated by the MAPK3/ERK1 and AKT1 pathway (By similarity).

Blocks TNFSF11/RANKL-induced osteoclast formation from macrophages by inhibiting up-regulation of osteoclast fusogenic and differentiation genes (By similarity).

Stimulation of macrophage migration and inhibition of osteoclast formation is mediated via GPCR FPR2 (By similarity).

Acts as an adipokine by negatively regulating vascular smooth muscle cell (VSMC) proliferation and migration in response to platelet-derived growth factor stimulation via GPCR S1PR2 and G protein GNA12/GNA13-transmitted RHOA signaling (By similarity).

Inhibits injury-induced cell proliferation and neointima formation in the femoral arteries (By similarity).
Biological Process
G protein-coupled receptor signaling pathway Source: MGI
Negative regulation of vascular associated smooth muscle cell migration Source: Ensembl
Negative regulation of vascular associated smooth muscle cell proliferation Source: MGI
Negative regulation of vascular wound healing Source: Ensembl
Cellular Location
Secreted

Wang, Y., Zhang, Z., Wan, W., Liu, Y., Jing, H., & Dong, F. (2022). FAM19A5/S1PR1 signaling pathway regulates the viability and proliferation of mantle cell lymphoma. Journal of Receptors and Signal Transduction, 42(3), 225-229.

Yari, F. A., Shabani, P., Karami, S., Sarmadi, N., Poustchi, H., & Bandegi, A. R. (2021). Circulating levels of FAM19A5 are inversely associated with subclinical atherosclerosis in non-alcoholic fatty liver disease. BMC Endocrine Disorders, 21(1), 1-7.

Huang, S., Zheng, C., Xie, G., Song, Z., Wang, P., Bai, Y., ... & Wang, Y. (2021). FAM19A5/TAFA5, a novel neurokine, plays a crucial role in depressive-like and spatial memory-related behaviors in mice. Molecular psychiatry, 26(6), 2363-2379.

Kang, D., Kim, H. R., Kim, K. K., Kim, D. H., Jeong, B., Jin, S., ... & Lee, B. J. (2020). Brain-specific chemokine FAM19A5 induces hypothalamic inflammation. Biochemical and biophysical research communications, 523(4), 829-834.

Han, K. M., Tae, W. S., Kim, A., Kang, Y., Kang, W., Kang, J., ... & Ham, B. J. (2020). Serum FAM19A5 levels: a novel biomarker for neuroinflammation and neurodegeneration in major depressive disorder. Brain, behavior, and immunity, 87, 852-859.

Li, J., Li, S., Song, Y., Zhou, W., Zhu, X., Xu, S., ... & Zhu, C. (2020). Association of serum FAM19A5 with cognitive impairment in vascular dementia. Disease Markers, 2020.

Toussi, A., Merleev, A., Barton, V., Le, S., Marusina, A. I., Luxardi, G., ... & Maverakis, E. (2020). 17083 Identification of psoriasis-protective IL-17D variant associated with increased IL-17D and FAM19A5 expression in psoriatic skin. Journal of the American Academy of Dermatology, 83(6), AB78.

Shahapal, A., Cho, E. B., Yong, H. J., Jeong, I., Kwak, H., Lee, J. K., ... & Seong, J. Y. (2019). FAM19A5 expression during embryogenesis and in the adult traumatic brain of FAM19A5-LacZ knock-in mice. Frontiers in neuroscience, 13, 917.

Lee, Y. B., Hwang, H. J., Kim, J. A., Hwang, S. Y., Roh, E., Hong, S. H., ... & Yoo, H. J. (2019). Association of serum FAM19A5 with metabolic and vascular risk factors in human subjects with or without type 2 diabetes. Diabetes and Vascular Disease Research, 16(6), 530-538.

Wang, Y., Chen, D., Zhang, Y., Wang, P., Zheng, C., Zhang, S., ... & Kong, W. (2018). Novel adipokine, FAM19A5, inhibits neointima formation after injury through sphingosine-1-phosphate receptor 2. Circulation, 138(1), 48-63.

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For research use only. Not intended for any clinical use.

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