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Mouse Anti-FERMT2 Recombinant Antibody (14A11) (CBMAB-K0328-LY)

This product is antibody recognizes FERMT2. The antibody 14A11 immunoassay techniques such as: IF, IHC-P, IP, WB.
See all FERMT2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
14A11
Antibody Isotype
IgG2a
Application
IF, IHC-P, IP, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
FERMITIN FAMILY MEMBER 2
Entrez Gene ID
10979
UniProt ID
Q96AC1
Alternative Names
MIG2; KIND2; mig-2; UNC112; PLEKHC1; UNC112B
Research Area
Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling.
Biological Process
Adherens junction maintenance Source: ARUK-UCL
Cell adhesion Source: ARUK-UCL
Cell-matrix adhesion Source: UniProtKB
Focal adhesion assembly Source: ARUK-UCL
Integrin activation Source: UniProtKB
Integrin-mediated signaling pathway Source: UniProtKB
Limb development Source: Ensembl
Negative regulation of cell death Source: ARUK-UCL
Negative regulation of fat cell differentiation Source: ARUK-UCL
Negative regulation of vascular permeability Source: ARUK-UCL
Positive regulation of cell migration Source: ARUK-UCL
Positive regulation of epithelial to mesenchymal transition Source: ARUK-UCL
Positive regulation of ERK1 and ERK2 cascade Source: ARUK-UCL
Positive regulation of focal adhesion assembly Source: ARUK-UCL
Positive regulation of GTPase activity Source: ARUK-UCL
Positive regulation of integrin activation Source: ARUK-UCL
Positive regulation of mesenchymal stem cell proliferation Source: ARUK-UCL
Positive regulation of myosin light chain kinase activity Source: ARUK-UCL
Positive regulation of osteoblast differentiation Source: ARUK-UCL
Positive regulation of protein kinase B signaling Source: ARUK-UCL
Positive regulation of protein localization to nucleus Source: ARUK-UCL
Positive regulation of stress fiber assembly Source: ARUK-UCL
Positive regulation of substrate adhesion-dependent cell spreading Source: ARUK-UCL
Positive regulation of wound healing, spreading of epidermal cells Source: ARUK-UCL
Protein localization to cell junction Source: ARUK-UCL
Protein localization to membrane Source: UniProtKB
Regulation of cell morphogenesis Source: ARUK-UCL
Regulation of cell shape Source: UniProtKB-KW
Substrate adhesion-dependent cell spreading Source: UniProtKB
Transforming growth factor beta receptor signaling pathway Source: UniProtKB
Wnt signaling pathway Source: UniProtKB
Cellular Location
Nucleus; Lamellipodium membrane; Cytoskeleton; Stress fiber; Cytoplasm; Cell cortex; Focal adhesion; Membrane; I band; Cell surface. Colocalizes with actin stress fibers at cell-ECM focal adhesion sites. Colocalizes with ITGB3 at lamellipodia at the leading edge of spreading cells. Binds to membranes that contain phosphatidylinositides.

Xia, W., Gao, Z., Jiang, X., Jiang, L., Qin, Y., Zhang, D., ... & Xu, S. (2022). Alzheimer’s risk factor FERMT2 promotes the progression of colorectal carcinoma via Wnt/β-catenin signaling pathway and contributes to the negative correlation between Alzheimer and cancer. Plos one, 17(12), e0278774.

Eysert, F., Coulon, A., Boscher, E., Vreulx, A. C., Flaig, A., Mendes, T., ... & Chapuis, J. (2021). Alzheimer’s genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner. Molecular psychiatry, 26(10), 5592-5607.

Eysert, F., Coulon, A., Boscher, E., Vreulx, A. C., Flaig, A., Mendes, T., ... & Chapuis, J. (2021). Correction to: Alzheimer’s genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner. Molecular Psychiatry, 26(10), 5608-5608.

Yan, Y., Zhao, A., Qui, Y., Li, Y., Yan, R., Wang, Y., ... & Deng, Y. (2020). Genetic association of FERMT2, HLA-DRB1, CD2AP, and PTK2B polymorphisms with Alzheimer’s disease risk in the southern chinese population. Frontiers in aging neuroscience, 12, 16.

Guan, C., Yang, C., Wang, Y., & Xu, Y. (2020). Comment on ‘miR-338-5p inhibits cell proliferation, colony formation, migration, and cisplatin resistance in esophageal squamous cancer cells by targeting FERMT2’. Carcinogenesis, 41(2), 246-246.

Lin, W. C., Chen, L. H., Hsieh, Y. C., Yang, P. W., Lai, L. C., Chuang, E. Y., ... & Tsai, M. H. (2019). miR-338-5p inhibits cell proliferation, colony formation, migration and cisplatin resistance in esophageal squamous cancer cells by targeting FERMT2. Carcinogenesis, 40(7), 883-892.

Sullivan, S. E., Liao, M., Smith, R. V., White, C., Lagomarsino, V. N., Xu, J., ... & Young-Pearse, T. L. (2019). Candidate-based screening via gene modulation in human neurons and astrocytes implicates FERMT2 in A β and TAU proteostasis. Human molecular genetics, 28(5), 718-735.

Kawamura, E., Hamilton, G. B., Miskiewicz, E. I., & MacPhee, D. J. (2018). Fermitin family homolog-2 (FERMT2) is highly expressed in human placental villi and modulates trophoblast invasion. BMC Developmental Biology, 18(1), 1-13.

Yasuda-Yamahara, M., Rogg, M., Frimmel, J., Trachte, P., Helmstaedter, M., Schroder, P., ... & Huber, T. B. (2018). FERMT2 links cortical actin structures, plasma membrane tension and focal adhesion function to stabilize podocyte morphology. Matrix Biology, 68, 263-279.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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