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Rabbit Anti-FRMD6 Monoclonal Antibody (EPR12261) (CBMAB-1283-YC)

Provided herein is a rabbit monoclonal antibody against Human FRMD6. The antibody, clone EPR12261, can be used for immunoassay techniques, such as ICC, IF, FC, Cyt and WB.
See all FRMD6 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EPR12261
Antibody Isotype
IgG
Application
ICC, IF, FC, Cyt, WB

Basic Information

Immunogen
Recombinant fragment within Human FRMD6.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
FERM Domain Containing 6
Introduction
FERM domain-containing protein 6 (FRMD6) is a protein that in humans is encoded by the FRMD6 gene. FRMD6 has broad expression in esophagus, endometrium and other tissues
Entrez Gene ID
Human122786
Mouse319710
Rat257646
UniProt ID
HumanQ96NE9
MouseQ8C0V9
RatQ8VII0
Alternative Names
EX1; Willin; C14orf31; c14_5320
Biological Process
Actomyosin structure organization Source: GO_Central
Cellular Location
Cell membrane; Cytoplasm. Can colocalize with actin.

Sun, W., Lei, X., Lu, Q., Wu, Q., Ma, Q., Huang, D., & Zhang, Y. (2023). LncRNA FRMD6-AS1 Promotes Hepatocellular Carcinoma Cell Migration and Stemness by Regulating SENP1/HIF-1α Axis. Pathology-Research and Practice, 154377.

Shen, L., Dang, J., Liu, S., Xian, B., Deng, Y., & Qu, D. (2022). CircRNA VPRBP inhibits tumorigenicity of cervical cancer via miR-93-5p/FRMD6 axis. Reproductive Sciences, 29(8), 2251-2264.

Chen, D., Yu, W., Aitken, L., & Gunn-Moore, F. (2022). Willin/FRMD6 Mediates Mitochondrial Dysfunction Relevant to Neuronal Aβ Toxicity. Cells, 11(19), 3140.

Li, P., Wang, J., Zhi, L., & Cai, F. (2021). Linc00887 suppresses tumorigenesis of cervical cancer through regulating the miR-454-3p/FRMD6-Hippo axis. Cancer cell international, 21(1), 1-14.

Chen, D., Yu, W., Aitken, L., & Gunn-Moore, F. (2021). Willin/FRMD6: A Multi-Functional Neuronal Protein Associated with Alzheimer’s Disease. Cells, 10(11), 3024.

Haldrup, J., Strand, S. H., Cieza-Borrella, C., Jakobsson, M. E., Riedel, M., Norgaard, M., ... & Sorensen, K. D. (2021). FRMD6 has tumor suppressor functions in prostate cancer. Oncogene, 40(4), 763-776.

Wang, J., Li, Z., Wang, X., Ding, Y., & Li, N. (2020). The tumor suppressive effect of long non-coding RNA FRMD6-AS2 in uteri corpus endometrial carcinoma. Life sciences, 243, 117254.

Lyu, C., Lyu, G. W., Mulder, J., Uhlén, M., Cai, X. H., Hökfelt, T., & Sten Shi, T. J. (2020). Expression and regulation of FRMD6 in mouse DRG neurons and spinal cord after nerve injury. Scientific Reports, 10(1), 1880.

Kronenberg, N. M., Tilston-Lunel, A., Thompson, F. E., Chen, D., Yu, W., Dholakia, K., ... & Gunn-Moore, F. J. (2020). Willin/FRMD6 influences mechanical phenotype and neuronal differentiation in mammalian cells by regulating ERK1/2 activity. Frontiers in Cellular Neuroscience, 14, 552213.

Guan, C., Chang, Z., Gu, X., & Liu, R. (2019). MTA2 promotes HCC progression through repressing FRMD6, a key upstream component of hippo signaling pathway. Biochemical and biophysical research communications, 515(1), 112-118.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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