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Mouse Anti-GMDS Recombinant Antibody (CBLG1-2835) (CBMAB-G4002-LY)

This product is antibody recognizes GMDS. The antibody CBLG1-2835 immunoassay techniques such as: WB.
See all GMDS antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBLG1-2835
Antibody Isotype
IgG2a
Application
WB

Basic Information

Immunogen
Full length human recombinant protein of human GMDS (NP_001491) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol
Preservative
0.02% NaN3
Concentration
0.64 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
GDP-mannose 4, 6-dehydratase
Introduction
GDP-mannose 4,6-dehydratase (GMD; EC 4.2.1.47) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020).[supplied by OMIM, Aug 2009]
Entrez Gene ID
2762
UniProt ID
O60547
Alternative Names
GDP-Mannose 4;6-Dehydratase; Short Chain Dehydrogenase/Reductase Family 3E; Member 1; GDP-D-Mannose Dehydratase; EC 4.2.1.47; GMD; GDP-Mannose 4;6 Dehydratase; SDR3E1;
Function
Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
Biological Process
de novo' GDP-L-fucose biosynthetic process Source: UniProtKB
GDP-mannose metabolic process Source: UniProtKB
Notch signaling pathway Source: UniProtKB
Cellular Location
Cytosol; Extracellular exosome; Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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