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Rabbit Anti-GRIN2C Monoclonal Antibody (EPR18949) (CBMAB-1425-YC)

Provided herein is a rabbit monoclonal antibody against Mouse GRIN2C. The antibody, clone EPR18949, can be used for immunoassay techniques, such as WB.
See all GRIN2C antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse, Rat
Clone
EPR18949
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Recombinant fragment within Mouse NMDAR2C aa 1000 to the C-terminus.
Specificity
Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Glutamate Ionotropic Receptor NMDA Type Subunit 2C
Introduction
GRIN2C is a subunit that in combination with NMDAR1 displays NMDA receptor activity. GRIN2C may contribute to NMDA receptor functional diversity.
Entrez Gene ID
Mouse14813
Rat24411
UniProt ID
MouseQ01098
RatQ00961
Alternative Names
NR2C; GluN2C; NMDAR2C
Function
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg2+ (PubMed:26875626).

Sensitivity to glutamate and channel kinetics depend on the subunit composition (Probable). Plays a role in regulating the balance between excitatory and inhibitory activity of pyramidal neurons in the prefrontal cortex. Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similarity).
Biological Process
Brain development Source: ARUK-UCL
Calcium ion transmembrane import into cytosol Source: UniProtKB
Directional locomotion Source: Ensembl
Excitatory chemical synaptic transmission Source: ARUK-UCL
Excitatory postsynaptic potential Source: GO_Central
Glutamate receptor signaling pathway Source: ProtInc
Long-term synaptic potentiation Source: GO_Central
Negative regulation of protein catabolic process Source: Ensembl
Neuromuscular process controlling balance Source: Ensembl
Protein localization to postsynaptic membrane Source: Ensembl
Regulation of synaptic plasticity Source: ARUK-UCL
Response to wounding Source: Ensembl
Cellular Location
Cell membrane; Postsynaptic cell membrane
Topology
Extracellular: 20-554
Helical: 555-573
Cytoplasmic: 574-600
Discontinuously helical: 601-620
Cytoplasmic: 621-627
Helical: 628-643
Extracellular: 644-814
Helical: 815-834
Cytoplasmic: 835-1233
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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