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Mouse Anti-HCoV Spike glycoprotein Recombinant Antibody (CBMC-C0004) (CBMAB-V208-0153-CQ)

This product is a mouse antibody that recognizes HCoV Spike glycoprotein. The antibody CBMC-C0004 can be used for immunoassay techniques such as: ELISA, FC, IF.
See all HCoV Spike glycoprotein antibodies

Summary

Host Animal
Mouse
Specificity
HCoV
Clone
CBMC-C0004
Antibody Isotype
IgG1
Application
ELISA, FC, IF

Basic Information

Immunogen
Recombinant Human coronavirus spike glycoprotein protein
Specificity
HCoV
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Human Coronavirus Spike glycoprotein
Introduction
Spike protein S1: attaches the virion to the cell membrane by interacting with host receptor, initiating the infection. Binding to human ACE2 and CLEC4M/DC-SIGNR receptors and internalization of the virus into the endosomes of the host cell induces conformational changes in the S glycoprotein. Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.UniRule annotation2 Publications. Spike protein S2: mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.
Alternative Names
HCoV Spike glycoprotein; Human Coronavirus Spike glycoprotein
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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