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Mouse Anti-IGSF3 Recombinant Antibody (503621) (CBMAB-I1377-YY)

This product is Mouse antibody that recognizes IGSF3. The antibody 503621 can be used for immunoassay techniques such as: WB, FC, CyTOF
See all IGSF3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
503621
Antibody Isotype
IgG1
Application
WB, FC, CyTOF

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Antibody
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
immunoglobulin superfamily, member 3
Introduction
The protein encoded by this gene is an immunoglobulin-like membrane protein containing several V-type Ig-like domains. A mutation in this gene has been associated with bilateral nasolacrimal duct obstruction (LCDD).
Entrez Gene ID
3321
UniProt ID
O75054
Alternative Names
Immunoglobulin Superfamily Member 3
Function
Lacrimal gland development Source: UniProtKB
Cellular Location
Membrane
Involvement in disease
Lacrimal duct defect (LCDD):
A condition resulting in the imbalance between tear production and tear drainage. Infants typically manifest persistent epiphora and/or recurrent infections of the lacrimal pathway, such as conjunctivitis. LCDD is caused by failure of the nasolacrimal duct to open into the inferior meatus.
Topology
Extracellular: 20-1124
Helical: 1125-1145
Cytoplasmic: 1146-1194

Curry, R. N., Aiba, I., Meyer, J., Lozzi, B., Ko, Y., McDonald, M. F., ... & Deneen, B. (2023). Glioma epileptiform activity and progression are driven by IGSF3-mediated potassium dysregulation. Neuron, 111(5), 682-695.

Venkataramani, V. (2023). IGSF3-mediated potassium dysregulation promotes neuronal hyperexcitability and glioma progression. Trends in Cancer.

Schweitzer, K., Egersdorf, N., Rivera, T., DuBois, B., Cornell, C., Borowiec, A., ... & Petrache, I. (2023). IGSF3 (immunoglobulin superfamily 3) and glycosphingolipids associated with lung cell proliferation during recovery from respiratory SARS-CoV-2 infection. Physiology, 38(S1), 5795558.

Peng, W., Xie, Y., Xia, J., Li, B., Zhang, F., Wen, F., ... & Zhang, L. (2022). Association of Circulating Biomarkers of lnc-IGSF3-1: 1, SCOC-AS1, and SLC8A1-AS1 with Salt Sensitivity of Blood Pressure in Chinese Population. Journal of Cardiovascular Translational Research, 15(4), 906-917.

Schweitzer, K., Nall, J., Foster, D., Ashner, Y., Sajuthi, S., Correll, K., ... & Petrache, I. (2021). Upregulation of IGSF3 expression by iron chelation leads to the inhibition of epithelial cell proliferation. The FASEB Journal, 35.

Sheng, P., Zhu, H., Zhang, W., Xu, Y., Peng, W., Sun, J., ... & Jiang, H. (2020). The immunoglobulin superfamily member 3 (igsf3) promotes hepatocellular carcinoma progression through activation of the nf-κb pathway. Annals of Translational Medicine, 8(6).

Schweitzer, K. S., Jinawath, N., Yonescu, R., Ni, K., Rush, N., Charoensawan, V., ... & Petrache, I. (2020). IGSF3 mutation identified in patient with severe COPD alters cell function and motility. JCI insight, 5(14).

Wang, F., Tao, H., Han, C., Bai, F., Wang, P., Zhou, X. B., ... & Liu, C. (2020). Preliminary report on screening IGSF3 gene mutation in families with congenital absence of lacrimal puncta and canaliculi. International Journal of Ophthalmology, 13(9), 1351.

Schweitzer, K., & Petrache, I. (2019). Role of IGSF3 in Lung Epithelial Barrier Disruption Induced by Cigarette Smoke Exposure. The FASEB Journal, 33(S1), 655-8.

Schweitzer, K., Ni, K., Jacobson, S., Bronova, I., Berdyshev, E., Bowler, R., & Petrache, I. (2018). The Role of IGSF3 in Cell Adhesion, Proliferation, and Cell Migration. Annals of the American Thoracic Society, 15(Supplement 4), S291-S291.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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