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Recombinant Mouse Anti-Influenza B Hemagglutinin HA2 Antibody (CB198) (CBMAB-MD863-LY)

The product is antibody recognizes Influenza B Virus. The antibody CB198 immunoassay techniques such as: ELISA, WB.
See all Influenza B Hemagglutinin HA2 antibodies

Summary

Host Animal
Mouse
Specificity
Influenza B Virus
Clone
CB198
Antibody Isotype
IgG2b
Application
ELISA, WB

Basic Information

Immunogen
Purified Influenza B Virus
Specificity
Influenza B Virus
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
0.09% Sodium Azide
Purity
> 90% Purity determined by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Influenza B Hemagglutinin HA2
Function
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induce an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.
Biological Process
Endocytosis involved in viral entry into host cellIEA:UniProtKB-KW
Fusion of virus membrane with host endosome membraneIEA:UniProtKB-UniRule
Fusion of virus membrane with host plasma membraneIEA:InterPro
Viral budding from plasma membraneIEA:UniProtKB-UniRule
Virion attachment to host cellIEA:UniProtKB-KW
Cellular Location
Virion membrane; Host apical cell membrane. Targeted to the apical plasma membrane in epithelial polarized cells through a signal present in the transmembrane domain. Associated with glycosphingolipid- and cholesterol-enriched detergent-resistant lipid rafts.
Topology
Extracellular: 16-551
Helical: 552-572
Cytoplasmic: 573-583
PTM
Palmitoylated.
In natural infection, inactive HA is matured into HA1 and HA2 outside the cell by one or more trypsin-like, arginine-specific endoprotease secreted by the bronchial epithelial cells. One identified protease that may be involved in this process is secreted in lungs by Clara cells.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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