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Mouse Anti-KCNA3 Recombinant Antibody (CBMAB-K0478-LY)

This product is antibody recognizes KCNA3. The antibody immunoassay techniques such as: IHC, IF, EM, WB.
See all KCNA3 antibodies

Summary

Host Animal
Mouse
Specificity
Rat, Human, Mouse
Antibody Isotype
IgG2a
Application
IHC, IF, EM, WB

Basic Information

Immunogen
Kv1.3 Antibody was produced in mice by repeated immunizations raised against a synthetic peptide at the cytoplasmic C-terminus region of rat Kv1.3
Specificity
Rat, Human, Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
potassium voltage-gated channel, shaker-related subfamily, member 3
Introduction
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human3738
Mouse16491
Rat29731
UniProt ID
HumanP22001
MouseP16390
RatP15384
Function
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
Biological Process
Potassium ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Potassium ion transportManual Assertion Based On ExperimentTAS:ProtInc
Protein homooligomerizationIEA:InterPro
Regulation of ion transmembrane transportIEA:UniProtKB-KW
Cellular Location
Cell membrane
Topology
Cytoplasmic: 1-234
Helical: 235-253
Extracellular: 254-294
Helical: 295-316
Cytoplasmic: 317-327
Helical: 328-348
Extracellular: 349-362
Helical: 363-381
Cytoplasmic: 382-397
Helical: 398-417
Extracellular: 418-458
Helical: 459-481
Cytoplasmic: 482-575
PTM
N-glycosylation promotes the cell surface expression.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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