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Rabbit Anti-LHX2 Monoclonal Antibody (EPR20449) (CBMAB-1377-YC)

Provided herein is a rabbit monoclonal antibody against Rat LHX2. The antibody, clone EPR20449, can be used for immunoassay techniques, such as IHC-Fr, IHC-P, IP and WB.
See all LHX2 antibodies

Summary

Host Animal
Rabbit
Specificity
Rat, Mouse
Clone
EPR20449
Antibody Isotype
IgG
Application
IHC-Fr, IHC-P, IP, WB

Basic Information

Immunogen
Recombinant fragment within Rat Lhx2 aa 1 to the C-terminus.
Specificity
Rat, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
LHX2
Introduction
LHX2 is a LIM domain transcription factor which involved in lymphoid and neural differentiation.
Entrez Gene ID
Mouse16870
Rat296706
UniProt ID
MouseQ9Z0S2
RatP36198
Alternative Names
LH2A; Lh-2
Function
Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By similarity).
Biological Process
Axon extensionIEA:Ensembl
Axon guidanceIEA:Ensembl
Cerebral cortex developmentIEA:Ensembl
Dorsal/ventral pattern formationIEA:Ensembl
Hair follicle developmentIEA:Ensembl
Maintenance of epithelial cell apical/basal polarityIEA:Ensembl
Mesoderm developmentIEA:Ensembl
Negative regulation of gene expression, epigeneticIEA:Ensembl
Negative regulation of neurogenesisIEA:Ensembl
Negative regulation of transcription regulatory region DNA bindingIEA:Ensembl
Neural tube closureIEA:Ensembl
Neuron differentiationManual Assertion Based On ExperimentIBA:GO_Central
Olfactory bulb developmentIEA:Ensembl
Positive regulation of neural precursor cell proliferationIEA:Ensembl
Positive regulation of transcription, DNA-templatedISS:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Retina development in camera-type eyeIEA:Ensembl
Telencephalon regionalizationIEA:Ensembl
Cellular Location
Nucleus

Xiao, J., Xie, Y., Duan, Q., Liu, T., Ye, R., Duan, X., ... & Liu, F. (2023). LIM Homeobox 2 Increases Adhesion-Regulating Molecule 1 Transcription to Facilitate the Pathological Progression of Oxidized Low-Density Lipoprotein-Stimulated Atherosclerotic Cell Models. International Heart Journal, 64(4), 750-758.

Singh, N., Singh, D., Bhide, A., Sharma, R., Bhowmick, S., Patel, V., & Modi, D. (2023). LHX2 in germ cells control tubular organization in the developing mouse testis. Experimental Cell Research, 425(1), 113511.

Mosca, N., Khoubai, F. Z., Fedou, S., Carrillo-Reixach, J., Caruso, S., Rio-Alvarez, D., ... & Grosset, C. F. (2022). LIM homeobox-2 suppresses hallmarks of adult and pediatric liver cancers by inactivating MAPK/ERK and Wnt/beta-catenin pathways. Liver Cancer, 11(2), 126-140.

Singh, N., Singh, D., & Modi, D. (2022). LIM homeodomain (LIM-HD) genes and their co-regulators in developing reproductive system and disorders of sex development. Sexual Development, 16(2-3), 147-161.

Britton, J. C., Cooper, A. M., Pira, C. U., & Oberg, K. C. (2022). Regulation of LIM homeodomain 2 (Lhx2) in the distal limb bud during patterning and development. The FASEB Journal, 36.

Gao, P., Sun, N., Zhao, T., Sun, Y., Gu, J., Ma, D., ... & Qi, X. (2022). Identification of prognostic indicators, diagnostic markers, and possible therapeutic targets among LIM homeobox transcription factors in breast cancer. Cancer Innovation, 1(3), 252-269.

Wheaton, B. J., Häggström, S. L., Muppavarapu, M., González‐Castrillón, L. M., & Wilson, S. I. (2022). Alternative LIM homeodomain splice variants are dynamically regulated at key developmental steps in vertebrates. Developmental Dynamics, 251(7), 1223-1243.

Yasuoka, Y., & Taira, M. (2021). LIM homeodomain proteins and associated partners: Then and now. Current topics in developmental biology, 145, 113-166.

Miyoshi, M., Kakinuma, S., Kamiya, A., Tsunoda, T., Tsuchiya, J., Sato, A., ... & Watanabe, M. (2019). LIM homeobox 2 promotes interaction between human iPS-derived hepatic progenitors and iPS-derived hepatic stellate-like cells. Scientific Reports, 9(1), 2072.

Chou, S. J., & Tole, S. (2019). Lhx2, an evolutionarily conserved, multifunctional regulator of forebrain development. Brain research, 1705, 1-14.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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