Mouse Anti-LMTK3 Recombinant Antibody (6C5) (CBMAB-L1896-YJ)

Name: Mouse Anti-LMTK3 Recombinant Antibody (6C5)
SKU: CBMAB-L1896-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

6C5

Application

Immunogen

LMTK3 (XP_055866, 1151 a.a. ~ 1250 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 1151-1250

More Infomation

Target

Full Name

lemur tyrosine kinase 3

Introduction

Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. LMTK3 may also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription. LMTK3 is involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons (By similarity).

Entrez Gene ID

114783

UniProt ID

Q96Q04

Alternative Names

LMR3; TYKLM3; PPP1R101

Function

Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (PubMed:21602804).
Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons (By similarity).

Biological Process

Protein phosphorylationManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Membrane
Cell projection, axon
Cell projection, dendrite
Golgi apparatus membrane
Punctate pattern in cell projections.

Topology

Helical: 40-60

Agnarelli, A., Lauer Betrán, A., Papakyriakou, A., Vella, V., Samuels, M., Papanastasopoulos, P., ... & Giamas, G. (2023). The Inhibitory Properties of a Novel, Selective LMTK3 Kinase Inhibitor. International Journal of Molecular Sciences, 24(1), 865.

Krishnan, A., Dhamodharan, D., Sundaram, T., Sundaram, V., & Byun, H. S. (2022). Computational discovery of novel human LMTK3 inhibitors by high throughput virtual screening using NCI database. Korean Journal of Chemical Engineering, 39(6), 1368-1374.

Vella, V., Giamas, G., & Ditsiou, A. (2022). Diving into the dark kinome: lessons learned from LMTK3. Cancer Gene Therapy, 29(8-9), 1077-1079.

Wang, C., Yang, M., Gu, X., & Gu, Y. (2021). Lemur tyrosine kinase-3 (LMTK3) induces chemoresistance to cetuximab in colorectal cancer via the ERK/MAPK pathway. Bioengineered, 12(1), 6594-6605.

Ortiz, M. A., Michaels, H., Molina, B., Toenjes, S., Davis, J., Marconi, G. D., ... & Nefzi, A. (2020). Discovery of cyclic guanidine-linked sulfonamides as inhibitors of LMTK3 kinase. Bioorganic & Medicinal Chemistry Letters, 30(9), 127108.

Ditsiou, A., Cilibrasi, C., Simigdala, N., Papakyriakou, A., Milton-Harris, L., Vella, V., ... & Giamas, G. (2020). The structure-function relationship of oncogenic LMTK3. Science Advances, 6(46), eabc3099.

Jiang, T., Lu, X., Yang, F., Wang, M., Yang, H., & Xing, N. (2020). LMTK3 promotes tumorigenesis in bladder cancer via the ERK/MAPK pathway. FEBS Open Bio, 10(10), 2107-2121.

Cairns, J., Ingle, J. N., Kalari, K. R., Shepherd, L. E., Kubo, M., Goetz, M. P., ... & Wang, L. (2019). The lncRNA MIR2052HG regulates ERα levels and aromatase inhibitor resistance through LMTK3 by recruiting EGR1. Breast Cancer Research, 21(1), 1-17.

Klug, L. R., Bannon, A. E., Javidi-Sharifi, N., Town, A., Fleming, W. H., VanSlyke, J. K., ... & Heinrich, M. C. (2019). LMTK3 is essential for oncogenic KIT expression in KIT-mutant GIST and melanoma. Oncogene, 38(8), 1200-1210.

Sarma, H., & Mattaparthi, V. S. K. (2019). Structure-based virtual screening of high-affinity ATP-competitive inhibitors against human lemur tyrosine kinase-3 (LMTK3) domain: a novel therapeutic target for breast cancer. Interdisciplinary Sciences: Computational Life Sciences, 11(3), 527-541.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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