Mouse Anti-LMTK3 Recombinant Antibody (CBYCL-406) (CBMAB-L0307-YC)

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Basic Information

Host Animal
Mouse
Clone
CBYCL-406
Application
ELISA, WB
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
lemur tyrosine kinase 3
Introduction
LMTK3 (Lemur Tyrosine Kinase 3) is a protein coding gene. Among its related pathways are ERK Signaling and Akt Signaling. Gene Ontology annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. And an important paralog is AATK.
Entrez Gene ID
UniProt ID
Alternative Names
LMR3; PPP1R101; TYKLM3
Function
Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (PubMed:21602804).
Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons (By similarity).
Biological Process
Protein phosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Membrane
Cell projection, axon
Cell projection, dendrite
Golgi apparatus membrane
Punctate pattern in cell projections.
Topology
Helical: 40-60

Agnarelli, A., Lauer Betrán, A., Papakyriakou, A., Vella, V., Samuels, M., Papanastasopoulos, P., ... & Giamas, G. (2023). The Inhibitory Properties of a Novel, Selective LMTK3 Kinase Inhibitor. International Journal of Molecular Sciences, 24(1), 865.

Krishnan, A., Dhamodharan, D., Sundaram, T., Sundaram, V., & Byun, H. S. (2022). Computational discovery of novel human LMTK3 inhibitors by high throughput virtual screening using NCI database. Korean Journal of Chemical Engineering, 39(6), 1368-1374.

Vella, V., Giamas, G., & Ditsiou, A. (2022). Diving into the dark kinome: lessons learned from LMTK3. Cancer Gene Therapy, 29(8-9), 1077-1079.

Wang, C., Yang, M., Gu, X., & Gu, Y. (2021). Lemur tyrosine kinase-3 (LMTK3) induces chemoresistance to cetuximab in colorectal cancer via the ERK/MAPK pathway. Bioengineered, 12(1), 6594-6605.

Ortiz, M. A., Michaels, H., Molina, B., Toenjes, S., Davis, J., Marconi, G. D., ... & Nefzi, A. (2020). Discovery of cyclic guanidine-linked sulfonamides as inhibitors of LMTK3 kinase. Bioorganic & Medicinal Chemistry Letters, 30(9), 127108.

Ditsiou, A., Cilibrasi, C., Simigdala, N., Papakyriakou, A., Milton-Harris, L., Vella, V., ... & Giamas, G. (2020). The structure-function relationship of oncogenic LMTK3. Science Advances, 6(46), eabc3099.

Jiang, T., Lu, X., Yang, F., Wang, M., Yang, H., & Xing, N. (2020). LMTK3 promotes tumorigenesis in bladder cancer via the ERK/MAPK pathway. FEBS Open Bio, 10(10), 2107-2121.

Cairns, J., Ingle, J. N., Kalari, K. R., Shepherd, L. E., Kubo, M., Goetz, M. P., ... & Wang, L. (2019). The lncRNA MIR2052HG regulates ERα levels and aromatase inhibitor resistance through LMTK3 by recruiting EGR1. Breast Cancer Research, 21(1), 1-17.

Klug, L. R., Bannon, A. E., Javidi-Sharifi, N., Town, A., Fleming, W. H., VanSlyke, J. K., ... & Heinrich, M. C. (2019). LMTK3 is essential for oncogenic KIT expression in KIT-mutant GIST and melanoma. Oncogene, 38(8), 1200-1210.

Sarma, H., & Mattaparthi, V. S. K. (2019). Structure-based virtual screening of high-affinity ATP-competitive inhibitors against human lemur tyrosine kinase-3 (LMTK3) domain: a novel therapeutic target for breast cancer. Interdisciplinary Sciences: Computational Life Sciences, 11(3), 527-541.

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For research use only. Not intended for any clinical use.

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