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Mouse Anti-LOXL2 Recombinant Antibody (5D2) (CBMAB-A5051-LY)

The product is antibody recognizes LOXL2. The antibody 5D2 immunoassay techniques such as: WB, ELISA.
Host Species
Mouse
Application
WB, ELISA
Immunogen
LOXL2 (NP_002309, 675 a.a. ~ 773 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Antibody Isotype
IgG2b, κ
Specificity
Human
Clone
5D2
Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
Introduction
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq]
Alternative Name
LOR2; WS9-14
Entrez Gene ID

This product has been referenced in:

Zhan, X. H., Jiao, J. W., Zhang, H. F., Li, C. Q., Zhao, J. M., Liao, L. D., ... & Du, Z. P. (2017). A three‐gene signature from protein–protein interaction network of LOXL 2‐and actin‐related proteins for esophageal squamous cell carcinoma prognosis. Cancer medicine, 6(7), 1707-1719.

Li, T. Y., Xu, L. Y., Wu, Z. Y., Liao, L. D., Shen, J. H., Xu, X. E., ... & Li, E. M. (2012). Reduced nuclear and ectopic cytoplasmic expression of lysyl oxidase–like 2 is associated with lymph node metastasis and poor prognosis in esophageal squamous cell carcinoma. Human pathology, 43(7), 1068-1076.

Li, T., Li, D., Cheng, L., Wu, H., Gao, Z., Liu, Z., ... & Wang, S. (2010). Epithelial-mesenchymal transition induced by hepatitis C virus core protein in cholangiocarcinoma. Annals of surgical oncology, 17(7), 1937-1944.

Fujimoto, E., & Tajima, S. (2009). Reciprocal regulation of LOX and LOXL2 expression during cell adhesion and terminal differentiation in epidermal keratinocytes. Journal of dermatological science, 55(2), 91-98.

Wu, S., Zheng, Q., Xing, X., Dong, Y., Wang, Y., You, Y., ... & Zhao, Y. (2018). Matrix stiffness-upregulated LOXL2 promotes fibronectin production, MMP9 and CXCL12 expression and BMDCs recruitment to assist pre-metastatic niche formation. Journal of Experimental & Clinical Cancer Research, 37(1), 99.

Wong, C. C. L., Zhang, H., Gilkes, D. M., Chen, J., Wei, H., Chaturvedi, P., ... & Semenza, G. L. (2012). Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis. Journal of molecular medicine, 90(7), 803-815.

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For Research Use Only. Not For Clinical Use.
Cat CBMAB-A5051-LY
Conjugates
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Second antibody and isotype control