Mouse Anti-LSM16 Recombinant Antibody (4E3-3A4) (CBMAB-L2208-YJ)

Name: Mouse Anti-LSM16 Recombinant Antibody (4E3-3A4)
SKU: CBMAB-L2208-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

4E3-3A4

Application

ELISA, WB

Immunogen

Full length recombinant corresponding to aa 1-509 from human LSM16 (AAH11534) with GST tag. MW of the GST tag alone is 26kD.

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.2

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 1-509

More Infomation

Target

Full Name

enhancer of mRNA decapping 3 homolog (S. cerevisiae)

Introduction

LSM16 is a protein that is important in mRNA degradation. LSM16 is a component of a decapping complex that promotes efficient removal of the monomethylguanosine (m7G) cap from mRNAs, as part of the 5' to 3' mRNA decay pathway. Mutations in this gene have been identified in human patients with an autosomal recessive form of intellectual disability.

Entrez Gene ID

80153

UniProt ID

Q96F86

Alternative Names

YJDC; LSM16; MRT50; YJEFN2; hYjeF_N2-15q23; enhancer of mRNA-decapping protein 3; LSM16 homolog (EDC3, S. cerevisiae); enhancer of mRNA decapping 3 homolog; yjeF N-terminal domain-containing protein 2; yjeF domain containing; yjeF domain-containing protein 1

Function

Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping. May play a role in spermiogenesis and oogenesis.

Biological Process

Deadenylation-independent decapping of nuclear-transcribed mRNAManual Assertion Based On ExperimentIBA:GO_Central
P-body assemblyManual Assertion Based On ExperimentIBA:GO_Central
RNA phosphodiester bond hydrolysis, endonucleolyticIEA:GOC

Cellular Location

Cytoplasm, P-body
Processing bodies (PB).

Involvement in disease

Mental retardation, autosomal recessive 50 (MRT50):
A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT50 patients show mild intellectual disability and microcephaly.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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