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Recombinant Mouse Anti-Metapneumovirus (MPV) Fusion Protein Antibody (CB2861) (CBMAB-MD579-LY)

The product is antibody recognizes Metapneumovirus. The antibody CB2861 immunoassay techniques such as: ELISA, IFA, IHC.
See all Metapneumovirus (MPV) Fusion Protein antibodies

Summary

Host Animal
Mouse
Specificity
Metapneumovirus
Clone
CB2861
Antibody Isotype
IgG2a
Application
ELISA, IFA, IHC

Basic Information

Immunogen
Human MPV Strain NCL-145
Specificity
Metapneumovirus
Antibody Isotype
IgG2a
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2-7.4
Preservative
0.02% Sodium Azide
Purity
> 95% Purity determined by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Metapneumovirus (MPV) Fusion Protein
Function
Fusion glycoprotein F0:
Inactive precursor that is cleaved to give rise to the mature F1 and F2 fusion glycoproteins.

Fusion glycoprotein F1:
Class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and plasma cell membrane fusion, the coiled coil regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm. This fusion is pH independent and occurs at the plasma or endosomal membrane. The trimer of F1-F2 (F protein) also facilitates the attachment to host cell by binding to host heparan sulfate.

Fusion glycoprotein F2:
Major determinant of the species specificity of RSV infection (By similarity).

The trimer of F1-F2 (F protein) also facilitates the attachment to host cell by binding to host heparan sulfate (PubMed:22238303).
Biological Process
Fusion of virus membrane with host plasma membrane Source: UniProtKB-KW
Viral entry into host cell Source: UniProtKB-KW
Cellular Location
Virion membrane
Host cell membrane
Topology
Helical: 492-512
PTM
Fusion glycoprotein F0:
The F glycoprotein is synthesized as a F0 inactive precursor that is heavily N-glycosylated and processed.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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