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Mouse Anti-MYOM1 (AA 1586-1684) Recombinant Antibody (CBFYM-3014) (CBMAB-M3209-FY)

This product is mouse antibody that recognizes MYOM1. The antibody CBFYM-3014 can be used for immunoassay techniques such as: ELISA, WB.
See all MYOM1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-3014
Antibody Isotype
IgG1, k
Application
ELISA, WB

Basic Information

Immunogen
Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: EGKALNLTCN VWGDPPPEVS WLKNEKALAS DDHCNLKFEA GRTAYFTING VSTADSGKYG LVVKNKYGSE TSDFTVSVFI PEEEARMAAL ESLKGGKKA
Specificity
Human
Antibody Isotype
IgG1, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1586-1684

Target

Full Name
myomesin 1, 185kDa
Introduction
The giant protein titin, together with its associated proteins, interconnects the major structure of sarcomeres, the M bands and Z discs. The C-terminal end of the titin string extends into the M line, where it binds tightly to M-band constituents of apparent molecular masses of 190 kD and 165 kD. This protein, myomesin 1, like myomesin 2, titin, and other myofibrillar proteins contains structural modules with strong homology to either fibronectin type III or immunoglobulin C2 domains. Myomesin 1 and myomesin 2 each have a unique N-terminal region followed by 12 modules of motif I or motif II, in the arrangement II-II-I-I-I-I-I-II-II-II-II-II. The two proteins share 50% sequence identity in this repeat-containing region. The head structure formed by these 2 proteins on one end of the titin string extends into the center of the M band. The integrating structure of the sarcomere arises from muscle-specific members of the superfamily of immunoglobulin-like proteins. Alternatively spliced transcript variants encoding different isoforms have been identified.
Entrez Gene ID
8736
UniProt ID
P52179
Alternative Names
Myomesin 1; 190 KDa Connectin-Associated Protein; 190 KDa Titin-Associated Protein; Myomesin 1 (Skelemin) 185kDa; Myomesin Family Member 1; Myomesin 1, 185kDa; Skelemin
Function
Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.
Biological Process
Muscle contraction Source: GO_Central
Positive regulation of gene expression Source: CAFA
Positive regulation of protein secretion Source: CAFA
Protein kinase A signaling Source: CAFA
Cellular Location
M line
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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