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Mouse Anti-NPTX1 Recombinant Antibody (5G9) (CBMAB-N3272-WJ)

This product is a Mouse antibody that recognizes NPTX1. The antibody 5G9 can be used for immunoassay techniques such as: WB.
See all NPTX1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
5G9
Antibody Isotype
IgG1
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
neuronal pentraxin I
Introduction
NPTX1 is a member of the neuronal pentraxin gene family. Neuronal pentraxin 1 is similar to the rat NP1 gene which encodes a binding protein for the snake venom toxin taipoxin. Human NPTX1 mRNA is exclusively localized to the nervous system. [provided by RefSeq, Jul 2008]
Entrez Gene ID
4884
UniProt ID
Q15818
Alternative Names
Neuronal Pentraxin 1; Neuronal Pentraxin I; NP-I; NP1; Neuronal Pentraxin-1;
Function
May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses.
Biological Process
Axonogenesis involved in innervationManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to glucose stimulusIEA:Ensembl
Cellular response to potassium ionIEA:Ensembl
Central nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Chemical synaptic transmissionManual Assertion Based On ExperimentTAS:ProtInc
Mitochondrial fragmentation involved in apoptotic processIEA:Ensembl
Mitochondrial transportIEA:Ensembl
Neurotransmitter receptor localization to postsynaptic specialization membraneIEA:Ensembl
Regulation of postsynaptic density assemblyIEA:Ensembl
Regulation of postsynaptic neurotransmitter receptor activityManual Assertion Based On ExperimentIDA:SynGO
Cellular Location
Cytoplasmic vesicle, secretory vesicle

Warth Perez Arias, C. C., Silbern, I., Caldi Gomes, L., Wartmann, H., Dambeck, V., Fanz, J., ... & Lingor, P. (2023). Proteomic analysis of the human hippocampus identifies neuronal pentraxin 1 (NPTX1) as synapto‐axonal target in late‐stage Parkinson's disease. Journal of Neurochemistry, 166(5), 862-874.

Zhu, H., Zhang, P., Shi, J., Kou, D., & Bai, X. (2023). Exosome-delivered circRPS5 inhibits the progression of melanoma via regulating the miR-151a/NPTX1 axis. Plos one, 18(6), e0287347.

Sun, Y., Xie, L., Ren, X., Ran, L., He, H., Kong, F., ... & Zhang, M. (2023). miR‐148a‐3p regulates proliferation and apoptosis of idiopathic gingival fibroma by targeting NPTX1. Oral Diseases.

Coutelier, M., Jacoupy, M., Janer, A., Renaud, F., Auger, N., Saripella, G. V., ... & Stevanin, G. (2022). NPTX1 mutations trigger endoplasmic reticulum stress and cause autosomal dominant cerebellar ataxia. Brain, 145(4), 1519-1534.

Li, H., Yan, R., Chen, W., Ding, X., Liu, J., Chen, G., ... & Yu, Y. (2021). Long non coding RNA SLC26A4‐AS1 exerts antiangiogenic effects in human glioma by upregulating NPTX1 via NFKB1 transcriptional factor. The FEBS Journal, 288(1), 212-228.

Lu, S., Zhou, C., Zou, B., Zhang, H., & Feng, M. (2020). MiR-4295 facilitates cell proliferation and metastasis in head and neck squamous cell carcinoma by targeting NPTX1. Genes & Immunity, 21(1), 4-12.

Huo, L., Wang, B., Zheng, M., Zhang, Y., Xu, J., Yang, G., & Guan, Q. (2019). miR‑128‑3p inhibits glioma cell proliferation and differentiation by targeting NPTX1 through IRS‑1/PI3K/AKT signaling pathway. Experimental and therapeutic medicine, 17(4), 2921-2930.

Su, X., Su, J., He, H., Zhan, Y., & Liu, H. (2019). Hsa_circ_0070269 inhibits hepatocellular carcinoma progression through modulating miR-182/NPTX1 axis. Biomedicine & Pharmacotherapy, 120, 109497.

Yan, H., Zheng, C., Li, Z., Bao, B., Yang, B., Hou, K., ... & Liu, Y. (2019). NPTX1 promotes metastasis via integrin/FAK signaling in gastric cancer. Cancer Management and Research, 11, 3237.

Zhao, Y., Yu, Y., Zhao, W., You, S., Feng, M., Xie, C., ... & Wang, X. (2019). As a downstream target of the AKT pathway, NPTX1 inhibits proliferation and promotes apoptosis in hepatocellular carcinoma. Bioscience reports, 39(6), BSR20181662.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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