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Rabbit Anti-OPRK1 Monoclonal Antibody (EPR18881) (CBMAB-1364-YC)

Provided herein is a rabbit monoclonal antibody against Mouse OPRK1. The antibody, clone EPR18881, can be used for immunoassay techniques, such as IP, IHC-P and WB.
See all OPRK1 antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse, Rat
Clone
EPR18881
Antibody Isotype
IgG
Application
IP, IHC-P, WB

Basic Information

Immunogen
Synthetic peptide within Mouse Kappa Opioid Receptor aa 300 to the C-terminus.
Specificity
Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Opioid Receptor Kappa 1
Introduction
OPRK1 is an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. OPRK1 plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids.
Entrez Gene ID
Mouse18387
Rat29335
UniProt ID
MouseP33534
RatP34975
Alternative Names
KOR; OPRK; KOR-1; K-OR-1
Function
G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.
Biological Process
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Adenylate cyclase-inhibiting opioid receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Behavioral response to cocaineIEA:Ensembl
Cellular response to glucose stimulusIEA:Ensembl
Cellular response to lipopolysaccharideIEA:Ensembl
Chemical synaptic transmissionManual Assertion Based On ExperimentTAS:ProtInc
Conditioned place preferenceIEA:Ensembl
Defense response to virusManual Assertion Based On ExperimentIDA:UniProtKB
Eating behaviorIEA:Ensembl
Estrous cycleIEA:Ensembl
G protein-coupled opioid receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Immune responseManual Assertion Based On ExperimentIDA:UniProtKB
Locomotory behaviorISS:UniProtKB
Maternal behaviorIEA:Ensembl
Negative regulation of luteinizing hormone secretionIEA:Ensembl
Neuropeptide signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Phospholipase C-activating G protein-coupled receptor signaling pathwayISS:UniProtKB
Positive regulation of dopamine secretionIEA:Ensembl
Positive regulation of eating behaviorIEA:Ensembl
Positive regulation of locomotionIEA:Ensembl
Positive regulation of p38MAPK cascadeIEA:Ensembl
Positive regulation of potassium ion transmembrane transportIEA:Ensembl
Regulation of saliva secretionISS:UniProtKB
Regulation of sensory perception of painIEA:Ensembl
Response to acrylamideIEA:Ensembl
Response to estrogenIEA:Ensembl
Response to ethanolIEA:Ensembl
Response to insulinIEA:Ensembl
Response to morphineIEA:Ensembl
Response to radiationIEA:Ensembl
Sensory perceptionManual Assertion Based On ExperimentTAS:ProtInc
Sensory perception of painISS:UniProtKB
Sensory perception of temperature stimulusIEA:Ensembl
Cellular Location
Cell membrane
Topology
Extracellular: 1-57
Helical: 58-85
Cytoplasmic: 86-95
Helical: 96-119
Extracellular: 120-132
Helical: 133-154
Cytoplasmic: 155-173
Helical: 174-196
Extracellular: 197-222
Helical: 223-247
Cytoplasmic: 248-274
Helical: 275-296
Extracellular: 297-311
Helical: 312-333
Cytoplasmic: 334-380

Shao, J., Fei, Y., Xiao, J., Wang, L., Zou, S., & Yang, J. (2023). The role of miRNA-144-3p/Oprk1/KOR in nicotine dependence and nicotine withdrawal in male rats. Nicotine and Tobacco Research, 25(12), 1856-1864.

Lepreux, G., Shinn, G. E., Wei, G., Suko, A., Concepcion, G., Sirohi, S., ... & Walker, B. M. (2023). Recapitulating phenotypes of alcohol dependence via overexpression of Oprk1 in the ventral tegmental area of non-dependent TH:: Cre rats. Neuropharmacology, 228, 109457.

Nagae, M., Yamada, K., Enomoto, Y., Kometani, M., Tsuchida, H., Panthee, A., ... & Uenoyama, Y. (2023). Conditional Oprk1-dependent Kiss1 deletion in kisspeptin neurons caused estrogen-dependent LH pulse disruption and LH surge attenuation in female rats. Scientific Reports, 13(1), 20495.

Özkan-Kotiloğlu, S., Kaya-Akyüzlü, D., Yurdakul, R., Yıldırım, M. A., & Özgür-İlhan, İ. (2023). Effect of PDYN and OPRK1 polymorphisms on the risk of alcohol use disorder and the intensity of depressive symptoms. Alcohol and Alcoholism, 58(4), 404-414.

Özkan-Kotiloğlu, S., Kaya-Akyüzlü, D., Yalçın-Şahiner, Ş., & Ayaz, N. (2023). Association of OPRK1 rs963549 and rs997917 polymorphisms with opioid use disorder and related phenotypes. Pharmacogenomics, 24(6), 325-334.

Özkan-Kotiloğlu, S. (2023). Detecting the OPRK1 rs963549 and rs997917 Polymorphisms by Novel PCR-RFLP Methods and Determining Their Genotype/Allele Frequencies in a Turkish Population. Biology Bulletin, 50(5), 801-807.

Yuferov, V., Butelman, E. R., Randesi, M., Ott, J., & Kreek, M. J. (2022). Analyses of polymorphisms of intron 2 of OPRK1 (kappa-opioid receptor gene) in association with opioid and cocaine dependence diagnoses in an African-American population. Neuroscience Letters, 768, 136364.

Coutinho, E. A., Esparza, L. A., Hudson, A. D., Rizo, N., Steffen, P., & Kauffman, A. S. (2022). Conditional deletion of KOR (Oprk1) in kisspeptin cells does not alter LH pulses, puberty, or fertility in mice. Endocrinology, 163(12), bqac175.

Albonaim, A., Sharafshah, A., & Keshavarz, P. (2021). Haplotype-based association study of Opioid Receptor Kappa-type 1 (OPRK1) gene polymorphisms with nicotine dependence among male smokers. British Journal of Biomedical Science, 78(3), 151-153.

Ho, K. W. D., Wallace, M. R., Staud, R., & Fillingim, R. B. (2020). OPRM1, OPRK1, and COMT genetic polymorphisms associated with opioid effects on experimental pain: a randomized, double-blind, placebo-controlled study. The pharmacogenomics journal, 20(3), 471-481.

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For research use only. Not intended for any clinical use.

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