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Rabbit Anti-PAFAH1B3 Recombinant Antibody (EPR11231) (CBMAB-1645-CN)

This product is a rabbit antibody that recognizes PAFAH1B3 of human. The antibody EPR11231 can be used for immunoassay techniques such as: WB, FC.
See all PAFAH1B3 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
EPR11231
Antibody Isotype
IgG
Application
WB, FC

Basic Information

Immunogen
Synthetic peptide within Human PAFAH1B3.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% Glycerol, 0.05% BSA
Preservative
0.01% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDa
Introduction
This gene encodes an acetylhydrolase that catalyzes the removal of an acetyl group from the glycerol backbone of platelet-activating factor. The encoded enzyme is a subunit of the platelet-activating factor acetylhydrolase isoform 1B complex, which consists of the catalytic beta and gamma subunits and the regulatory alpha subunit. Inactivates paf by removing the acetyl group at the sn-2 position. This is a catalytic subunit. This protein plays an important role during the development of brain.
Entrez Gene ID
UniProt ID
Alternative Names
PAFAHG
Function
Alpha1 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF. The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. Both alpha1/alpha1 homodimer (PAFAH1B3/PAFAH1B3 homodimer) and alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B2 heterodimer) hydrolyze 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA) more efficiently than PAF, but they have little hydrolytic activity towards 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE). Plays an important role during the development of brain.
Biological Process
Brain developmentManual Assertion Based On ExperimentIBA:GO_Central
Lipid catabolic processIEA:UniProtKB-KW
Lipid metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
SpermatogenesisIEA:Ensembl
Cellular Location
Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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