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Rabbit Anti-Phospho-DUSP1 (Ser359) Recombinant Antibody (125E1) (CBMAB-CP0513-LY)

The product is antibody recognizes Phospho-DUSP1 (Ser359). The antibody 125E1 immunoassay techniques such as: WB,IP.
See all Phospho-DUSP1 (Ser359) antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
125E1
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser359 of human DUSP1.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Dual Specificity Phosphatase 1
Introduction
The protein encoded by this gene is a phosphatase with dual specificity for tyrosine and threonine. The encoded protein can dephosphorylate MAP kinase MAPK1/ERK2, which results in its involvement in several cellular processes. This protein appears to play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. Finally, the encoded protein can make some solid tumors resistant to both chemotherapy and radiotherapy, making it a target for cancer therapy. [provided by RefSeq, Aug 2017]
Entrez Gene ID
UniProt ID
Alternative Names
Dual Specificity Phosphatase 1; Mitogen-Activated Protein Kinase Phosphatase 1; Dual Specificity Protein Phosphatase HVH1; Protein-Tyrosine Phosphatase CL100; MAP Kinase Phosphatase 1; PTPN10; CL100; MKP-1; MKP1;
Biological Process
Cell cycle Source: UniProtKB-KW
Cellular response to chemokine Source: BHF-UCL
Cellular response to hormone stimulus Source: Ensembl
Endoderm formation Source: GO_Central
Inactivation of MAPK activity Source: UniProtKB
Intracellular signal transduction Source: Ensembl
Negative regulation of apoptotic process Source: Ensembl
Negative regulation of cell adhesion Source: BHF-UCL
Negative regulation of DNA biosynthetic process Source: Ensembl
Negative regulation of ERK1 and ERK2 cascade Source: Ensembl
Negative regulation of MAPK cascade Source: UniProtKB
Negative regulation of MAP kinase activity Source: UniProtKB
Negative regulation of meiotic cell cycle Source: UniProtKB
Negative regulation of monocyte chemotaxis Source: BHF-UCL
Negative regulation of p38MAPK cascade Source: BHF-UCL
Peptidyl-serine dephosphorylation Source: UniProtKB
Peptidyl-threonine dephosphorylation Source: UniProtKB
Peptidyl-tyrosine dephosphorylation Source: UniProtKB
Positive regulation of apoptotic process Source: Ensembl
Protein dephosphorylation Source: GO_Central
Regulation of cell cycle Source: UniProtKB
Regulation of mitotic cell cycle spindle assembly checkpoint Source: UniProtKB
Response to calcium ion Source: Ensembl
Response to cAMP Source: Ensembl
Response to estradiol Source: Ensembl
Response to glucocorticoid Source: Ensembl
Response to hydrogen peroxide Source: Ensembl
Response to light stimulus Source: Ensembl
Response to retinoic acid Source: Ensembl
Response to testosterone Source: Ensembl
Cellular Location
Nucleus
PTM
Phosphorylation at Ser-359 and Ser-364 by MAPK1/ERK2 and MAPK3/ERK1 reduces its rate of degradation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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