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Rabbit Anti-Phospho-GIT2 (Tyr592) Recombinant Antibody (D6L1J) (CBMAB-CP0830-LY)

The product is antibody recognizes Phospho-GIT2 (Tyr592). The antibody D6L1J immunoassay techniques such as: WB.
See all Phospho-GIT2 (Tyr592) antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
D6L1J
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr592 of human GIT2 protein.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
GIT ArfGAP 2
Introduction
This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding. [provided by RefSeq, Sep 2008]
Entrez Gene ID
UniProt ID
Alternative Names
GIT ArfGAP 2; G Protein-Coupled Receptor Kinase Interacting ArfGAP 2; Cool-Interacting Tyrosine-Phosphorylated Protein 2; G Protein-Coupled Receptor Kinase-Interactor 2; GRK-Interacting Protein 2; Paxillin Kinase Linker; ARF GAP GIT2; CAT-2;
Function
GTPase-activating protein for ADP ribosylation factor family members, including ARF1.
Biological Process
Regulation of G protein-coupled receptor signaling pathway Source: ProtInc
Cellular Location
Nucleoplasm; Focal adhesion
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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