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Rabbit Anti-Phospho-MARCKS (Ser159/163) Recombinant Antibody (D13D2) (CBMAB-CP1456-LY)

The product is antibody recognizes Phospho-MARCKS (Ser159/163). The antibody D13D2 immunoassay techniques such as: WB,IP.
See all Phospho-MARCKS (Ser159/163) antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey, Chicken, Frog, Zebrafish, Cattle, Pig
Clone
D13D2
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser159 and Ser163 of human MARCKS protein.
Specificity
Human, Mouse, Rat, Monkey, Chicken, Frog, Zebrafish, Cattle, Pig
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Myristoylated Alanine Rich Protein Kinase C Substrate
Introduction
The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human4082
Mouse17118
Rat25603
Chicken396473
Cattle613548
Monkey694077
Frog448317
Pig100517207
UniProt ID
HumanP29966
MouseP26645
RatP30009
ChickenP16527
CattleP12624
MonkeyH9Z8Z3
FrogQ28ES5
PigA0A287BRL8
Alternative Names
Myristoylated Alanine Rich Protein Kinase C Substrate; Myristoylated Alanine-Rich Protein Kinase C Substrate (MARCKS; 80K-L); Protein Kinase C Substrate; 80 KDa Protein; Light Chain; PRKCSL; PKCSL; MACS;
Function
MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.
Biological Process
Actin crosslink formation Source: Ensembl
Actin filament bundle assembly Source: Ensembl
Actin filament organization Source: GO_Central
Central nervous system development Source: GO_Central
Cellular Location
Cytoskeleton
Other locations
Membrane
PTM
Phosphorylation by PKC displaces MARCKS from the membrane. It also inhibits the F-actin cross-linking activity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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