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Mouse Anti-BPIFA1 Recombinant Antibody (3C1) (CBMAB-A6822-LY)

The product is antibody recognizes PLUNC. The antibody 3C1 immunoassay techniques such as: WB, ELISA.
See all BPIFA1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3C1
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
PLUNC (AAH12549.1, 1 a.a. ~ 256 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Bpi Fold Containing Family A Member 1
Introduction
This gene is the human homolog of murine plunc, and like the mouse gene, is specifically expressed in the upper airways and nasopharyngeal regions. The exact biological function of this gene is not known, however, it has been suggested to be involved in inflammatory responses to irritants in the upper airways. It may also serve as a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer. Multiple transcript variants resulting from alternative splicing in the 3' UTR have been detected, but the full-length nature of only two is known. [provided by RefSeq]
Entrez Gene ID
UniProt ID
Alternative Names
LPLUNC3; LUNX; NASG; SPLUNC1; SPURT; bA49G10.5
Function
Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC) (PubMed:25223608).
Plays a role in the innate immune responses of the upper airways (PubMed:23499554, PubMed:23132494).
Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae (PubMed:23499554, PubMed:23132494, PubMed:27145151).
Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus (PubMed:24124190, PubMed:24043776).
Plays a role in the airway inflammatory response after exposure to irritants (PubMed:11425234).
May attract macrophages and neutrophils (PubMed:23132494).
Biological Process
Antibacterial humoral response Source: UniProtKB
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Antimicrobial humoral response Source: Reactome
Defense response to virus Source: UniProtKB
Immune response in nasopharyngeal-associated lymphoid tissue Source: UniProtKB
Innate immune response Source: UniProtKB
Multicellular organismal water homeostasis Source: UniProtKB
Negative regulation of single-species biofilm formation in or on host organism Source: UniProtKB
Regulation of liquid surface tension Source: UniProtKB
Regulation of sodium ion transmembrane transport Source: UniProtKB
Cellular Location
Secreted. Apical side of airway epithelial cells. Detected in airway surface liquid, nasal mucus and sputum.
PTM
May be N-glycosylated.

Zhang, R., Trower, J., & Wu, T. (2020). Degradation of bacterial permeability family member A1 (BPIFA1) by house dust mite (HDM) cysteine protease Der p 1 abrogates immune modulator function. International journal of biological macromolecules, 164, 4022-4031.

Saferali, A., Tang, A. C., Strug, L. J., Quon, B. S., Zlosnik, J., Sandford, A. J., & Turvey, S. E. (2020). Immunomodulatory function of the cystic fibrosis modifier gene BPIFA1. Plos one, 15(1), e0227067.

Britto, C. J., Niu, N., Khanal, S., Huleihel, L., Herazo-Maya, J. D., Thompson, A., ... & Cohn, L. E. (2019). BPIFA1 regulates lung neutrophil recruitment and interferon signaling during acute inflammation. American journal of physiology-lung cellular and molecular physiology, 316(2), L321-L333.

Khanal, S., Niu, N., Sharma, L., Liu, W., Cohn, L., Cruz, C. D., & Britto, C. (2019). BPI-fold containing Family A member 1 (Bpifa1) Role in IFN Driven Pulmonary Response.

Khanal, S., Niu, N., Huleihel, L., Herazo-Maya, J., Kaminski, N., Cohn, L., & Britto, C. (2018). BPI Fold-Containing Family A Member 1 (BPIFA1) regulates lung neutrophil recruitment and interferon signaling during acute inflammation.

Britto, C., Khanal, S., Wu, B., Li, Y., & Segal, L. (2018). BPI Fold Containing Family A Member 1 (BPIFA1) regulates mucosal microbiota and basal Interferon signaling.

Britto-Leon, C. J., Khanal, S., Wu, B., Li, Y., & Segal, L. N. (2018). BPI-Fold Containing Family A Member 1 (BPIFA1) Regulates Mucosal Immunity and Airway Microbiota. In D107. HOST PATHOGEN INTERACTIONS (pp. A7568-A7568). American Thoracic Society.

Wang, H., Jiang, D., Li, W., & Wang, S. (2017). Increased expression of BPI fold‑containing family A member 1 is associated with metastasis and poor prognosis in human colorectal carcinoma. Oncology letters, 14(4), 4231-4236.

Guo, Y., Guo, L. N., Zhu, J. F., Tang, C. Y., Feng, Y. Z., & Zhou, H. D. (2017). Associations of salivary BPIFA1 protein in chronic periodontitis patients with type 2 diabetes mellitus. International journal of endocrinology, 2017.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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