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Mouse Anti-PNN Recombinant Antibody (CBYC-P482) (CBMAB-P2270-YC)

Provided herein is a Mouse monoclonal antibody against Human Pinin, Desmosome Associated Protein. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all PNN antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYC-P482
Antibody Isotype
IgG2a
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.2, 0.09% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 201-301

Target

Full Name
pinin, desmosome associated protein
Introduction
PNN (Pinin, Desmosome Associated Protein) is a protein coding gene. Diseases associated with PNN include Premenstrual Tension and Epileptic Encephalopathy, Childhood-Onset. Among its related pathways are RNA transport and mRNA surveillance pathway. Gene Ontology annotations related to this gene include structural molecule activity.
Entrez Gene ID
5411
UniProt ID
Q9H307
Alternative Names
DRS; DRSP; SDK3; memA
Function
Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Component of the PSAP complex which binds RNA in a sequence-independent manner and is proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma.
Biological Process
Cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
mRNA splicing, via spliceosome1 PublicationIC:UniProtKB
Cellular Location
Nucleus speckle
Cell junction, desmosome
Cell-cell contact area, predominantly desmosome of intercellular adherens junction. Not a nucleocytoplasmic shuttling protein.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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