Sign in or Register   Sign in or Register
  |  

Mouse Anti-PPIF Recombinant Antibody (AT1F5) (CBMAB-C5671WJ)

This product is a Mouse antibody that recognizes PPIF. This antibody AT1F5 can be used for immunoassay techniques such as: ELISA, IHC-P, WB.
See all PPIF antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
AT1F5
Antibody Isotype
IgG2b
Application
ELISA, IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Peptidylprolyl Isomerase F
Introduction
PPIF (Peptidylprolyl Isomerase F) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Toxoplasmosis. Gene Ontology (GO) annotations related to this gene include peptide binding and cyclosporin A binding. An important paralog of this gene is PPIA.
Entrez Gene ID
UniProt ID
Alternative Names
CYP3; CypD; CyP-M; Cyp-D
Function
PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357).
Involved in regulation of the mitochondrial permeability transition pore (mPTP) (PubMed:26387735).
It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated (PubMed:26387735).
In cooperation with mitochondrial p53/TP53 is involved in activating oxidative stress-induced necrosis (PubMed:22726440).
Involved in modulation of mitochondrial membrane F1F0 ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels (By similarity).
Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis (PubMed:19228691).
Biological Process
Apoptotic mitochondrial changesIEA:Ensembl
Cellular response to arsenic-containing substanceISS:UniProtKB
Cellular response to calcium ionISS:UniProtKB
Cellular response to hydrogen peroxideManual Assertion Based On ExperimentIMP:UniProtKB
Mitochondrial outer membrane permeabilization involved in programmed cell deathManual Assertion Based On ExperimentIMP:UniProtKB
Necroptotic processIEA:Ensembl
Negative regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of ATP-dependent activityISS:UniProtKB
Negative regulation of intrinsic apoptotic signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of oxidative phosphorylationISS:UniProtKB
Negative regulation of oxidative phosphorylation uncoupler activityISS:UniProtKB
Negative regulation of release of cytochrome c from mitochondriaManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of release of cytochrome c from mitochondriaISS:UniProtKB
Protein foldingManual Assertion Based On ExperimentIBA:GO_Central
Protein peptidyl-prolyl isomerizationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of mitochondrial membrane permeabilityManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of mitochondrial membrane permeability involved in programmed necrotic cell deathManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of necrotic cell deathIEA:Ensembl
Regulation of proton-transporting ATPase activity, rotational mechanismISS:UniProtKB
Response to ischemiaISS:UniProtKB
Cellular Location
Mitochondrion matrix
PTM
Acetylated at Lys-167; deacetylated at Lys-167 by SIRT3.
Ask a question We look forward to hearing from you.
0 reviews or Q&As
Loading...
Have you used Mouse Anti-PPIF Recombinant Antibody (AT1F5)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare