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Mouse Anti-PPP3CA Recombinant Antibody (CC-6) (CBMAB-P2653-YC)

Provided herein is a Mouse monoclonal antibody against Cattle Protein Phosphatase 3 Catalytic Subunit Alpha. The antibody can be used for immunoassay techniques, such as IP.
See all PPP3CA antibodies

Summary

Host Animal
Mouse
Specificity
Cattle
Clone
CC-6
Antibody Isotype
IgG1
Application
IP

Basic Information

Specificity
Cattle
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.2, with 50 mMg sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
protein phosphatase 3 catalytic subunit alpha
Introduction
PPP3CA (Protein Phosphatase 3 Catalytic Subunit Alpha) is a protein coding gene. Diseases associated with PPP3CA include Epileptic Encephalopathy, Infantile Or Early Childhood, 1 and Undetermined Early-Onset Epileptic Encephalopathy. Among its related pathways are Antigen activates B Cell Receptor (BCR) leading to generation of second messengers and T cell receptor signaling pathway.
Entrez Gene ID
UniProt ID
Alternative Names
CALN; CALNA; CALNA1; CCN1; CNA1; PPP2B
Function
Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca2+-mediated signals (PubMed:15671020, PubMed:18838687, PubMed:19154138, PubMed:23468591, PubMed:30254215).
Many of the substrates contain a PxIxIT motif and/or a LxVP motif (PubMed:17498738, PubMed:17502104, PubMed:22343722, PubMed:23468591, PubMed:27974827).
In response to increased Ca2+ levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation (PubMed:15671020).
In response to increased Ca2+ levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion (PubMed:18838687).
Positively regulates the CACNA1B/CAV2.2-mediated Ca2+ release probability at hippocampal neuronal soma and synaptic terminals (By similarity).
Dephosphorylates heat shock protein HSPB1 (By similarity).
Dephosphorylates and activates transcription factor NFATC1 (PubMed:19154138).
In response to increased Ca2+ levels, regulates NFAT-mediated transcription probably by dephosphorylating NFAT and promoting its nuclear translocation (PubMed:26248042).
Dephosphorylates and inactivates transcription factor ELK1 (PubMed:19154138).
Dephosphorylates DARPP32 (PubMed:19154138).
May dephosphorylate CRTC2 at 'Ser-171' resulting in CRTC2 dissociation from 14-3-3 proteins (PubMed:30611118).
Dephosphorylates transcription factor TFEB at 'Ser-211' following Coxsackievirus B3 infection, promoting nuclear translocation (PubMed:33691586).
Required for postnatal development of the nephrogenic zone and superficial glomeruli in the kidneys, cell cycle homeostasis in the nephrogenic zone, and ultimately normal kidney function (By similarity).
Plays a role in intracellular AQP2 processing and localization to the apical membrane in the kidney, may thereby be required for efficient kidney filtration (By similarity).
Required for secretion of salivary enzymes amylase, peroxidase, lysozyme and sialic acid via formation of secretory vesicles in the submandibular glands (By similarity).
Required for calcineurin activity and homosynaptic depotentiation in the hippocampus (By similarity).
Required for normal differentiation and survival of keratinocytes and therefore required for epidermis superstructure formation (By similarity).
Positively regulates osteoblastic bone formation, via promotion of osteoblast differentiation (By similarity).
Positively regulates osteoclast differentiation, potentially via NFATC1 signaling (By similarity).
May play a role in skeletal muscle fiber type specification, potentially via NFATC1 signaling (By similarity).
Negatively regulates MAP3K14/NIK signaling via inhibition of nuclear translocation of the transcription factors RELA and RELB (By similarity).
Required for antigen-specific T-cell proliferation response (By similarity).
Biological Process
AgingIEA:Ensembl
Brain developmentIEA:Ensembl
Calcineurin-mediated signalingManual Assertion Based On ExperimentIMP:UniProtKB
Calcineurin-NFAT signaling cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Calcium ion transportIEA:Ensembl
Cardiac muscle hypertrophy in response to stressIEA:Ensembl
Cellular response to glucose stimulusIEA:Ensembl
Dendrite morphogenesisIEA:Ensembl
DephosphorylationManual Assertion Based On ExperimentTAS:UniProtKB
Epidermis developmentISS:UniProtKB
Excitatory postsynaptic potentialIEA:Ensembl
G1/S transition of mitotic cell cycleIEA:Ensembl
Keratinocyte differentiationISS:UniProtKB
Modulation of chemical synaptic transmissionISS:UniProtKB
Multicellular organismal response to stressIEA:Ensembl
Negative regulation of calcium ion import across plasma membrane1 PublicationIC:ComplexPortal
Negative regulation of chromatin bindingIEA:Ensembl
Negative regulation of dendrite morphogenesisIEA:Ensembl
Negative regulation of insulin secretionIEA:Ensembl
Negative regulation of miRNA maturationIEA:Ensembl
Negative regulation of signalingISS:UniProtKB
Negative regulation of voltage-gated calcium channel activity1 PublicationIC:ComplexPortal
Peptidyl-serine dephosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of activated T cell proliferationISS:UniProtKB
Positive regulation of calcineurin-NFAT signaling cascade2 PublicationsIC:ComplexPortal
Positive regulation of calcium ion import across plasma membrane1 PublicationIC:ComplexPortal
Positive regulation of cardiac muscle hypertrophy in response to stressIEA:Ensembl
Positive regulation of cell adhesionManual Assertion Based On ExperimentIMP:ARUK-UCL
Positive regulation of cell migrationManual Assertion Based On ExperimentIMP:ARUK-UCL
Positive regulation of connective tissue replacementIEA:Ensembl
Positive regulation of DNA-binding transcription factor activityIEA:Ensembl
Positive regulation of endocytosisIEA:Ensembl
Positive regulation of glomerulus developmentISS:UniProtKB
Positive regulation of osteoblast differentiationISS:UniProtKB
Positive regulation of osteoclast differentiationISS:UniProtKB
Positive regulation of saliva secretionISS:UniProtKB
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of voltage-gated calcium channel activity1 PublicationIC:ComplexPortal
Postsynaptic modulation of chemical synaptic transmissionIEA:Ensembl
Protein dephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein import into nucleusIEA:Ensembl
Regulation of cell proliferation involved in kidney morphogenesisISS:UniProtKB
Renal filtrationISS:UniProtKB
Response to amphetamineIEA:Ensembl
Response to calcium ionManual Assertion Based On ExperimentIDA:UniProtKB
Skeletal muscle fiber developmentISS:UniProtKB
Skeletal muscle tissue regenerationManual Assertion Based On ExperimentTAS:BHF-UCL
T cell activationManual Assertion Based On ExperimentTAS:UniProtKB
Transition between fast and slow fiberIEA:Ensembl
Wound healingManual Assertion Based On ExperimentTAS:BHF-UCL
Keywords
Cellular Location
Cytoplasm
Cell membrane
Cell membrane, sarcolemma
Cytoplasm, myofibril, sarcomere, Z line
Cell projection, dendritic spine
Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle (By similarity).
Recruited to the cell membrane by scaffold protein AKAP5 following L-type Ca2+-channel activation (PubMed:22343722).
Involvement in disease
Epileptic encephalopathy, infantile or early childhood, 1 (IECEE1):
A form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. IECEE1 is an autosomal dominant condition with onset of seizures between the first weeks and first years of life.
Arthrogryposis, cleft palate, craniosynostosis, and impaired intellectual development (ACCIID):
An autosomal dominant disease characterized by moderate to severe intellectual disability, craniosynostosis, cleft palate, micrognathia, arthrogryposis, and short stature. Some patients may present bone abnormalities and generalized seizures.
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For research use only. Not intended for any clinical use.

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