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Mouse Anti-CYTH3 Recombinant Antibody (6D3-1A9) (CBMAB-A7115-LY)

The product is antibody recognizes PSCD3. The antibody 6D3-1A9 immunoassay techniques such as: WB, ELISA.
See all CYTH3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
6D3-1A9
Antibody Isotype
IgG2b, κ
Application
WB, ELISA

Basic Information

Immunogen
PSCD3 (AAH08191, 1 a.a. ~ 180 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cytohesin 3
Introduction
This gene encodes a member of the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. PSCD family members have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This encoded protein is involved in the control of Golgi structure and function, and it may have a physiological role in regulating ADP-ribosylation factor protein 6 (ARF) functions, in addition to acting on ARF1. [provided by RefSeq]
Entrez Gene ID
9265
UniProt ID
O43739
Alternative Names
ARNO3; GRP1; PSCD3
Function
Promotes guanine-nucleotide exchange on ARF1 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays a role in the epithelial polarization (By similarity).
Biological Process
Establishment of epithelial cell polarity Source: UniProtKB
Golgi vesicle transport Source: UniProtKB
Positive regulation of cell adhesion Source: Ensembl
Regulation of ARF protein signal transduction Source: InterPro
Cellular Location
Cell membrane; Cytosol; Adherens junction; Tight junction. Translocates from the cytosol to membranes enriched in phosphatidylinositol 3,4,5-trisphosphate.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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