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Rabbit Anti-QKI Recombinant Antibody (EPR7306) (CBMAB-1744-CN)

This product is a rabbit antibody that recognizes QK of mouse. The antibody EPR7306 can be used for immunoassay techniques such as: WB, IP, IF.
See all QKI antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
EPR7306
Antibody Isotype
IgG
Application
WB, IP, IF

Basic Information

Immunogen
Synthetic peptide corresponding to amino acid residues in Human QKI. (UniProt ID: Q96PU8)
Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
49% PBS, 50% Glycerol, 0.05% BSA, pH 7.2
Preservative
0.1% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
QKI
Introduction
This is a RNA-binding protein that plays a central role in myelinization. This protein acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation, as well as cellular processes including apoptosis, cell cycle, glial cell fate and development.
Entrez Gene ID
Human9444
Mouse19317
Rat499022
UniProt ID
HumanQ96PU8
MouseQ9QYS9
RatQ91XU1
Alternative Names
QkI; l17Wis1; 1500005P18; l(17)-1Wis; 1110003F05Rik
Function
RNA-binding protein that plays a central role in myelinization (PubMed:16641098).
Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Regulates target mRNA stability (PubMed:23630077).
In addition, acts by regulating pre-mRNA splicing, mRNA export and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia (PubMed:16641098).
Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity).
Biological Process
Biological Process long-chain fatty acid biosynthetic processIEA:Ensembl
Biological Process mRNA processingIEA:UniProtKB-KW
Biological Process mRNA transportIEA:UniProtKB-KW
Biological Process myelinationIEA:Ensembl
Biological Process positive regulation of gene expressionIEA:Ensembl
Biological Process regulation of mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of translationIEA:UniProtKB-KW
Biological Process RNA splicingIEA:UniProtKB-KW
Biological Process spermatid developmentIEA:Ensembl
Biological Process vascular associated smooth muscle cell differentiationIEA:Ensembl
Biological Process vasculogenesisIEA:Ensembl
Cellular Location
Nucleus
Cytoplasm
PTM
Methylated by PRMT1.
Tyrosine phosphorylated at its C-terminus, probably by FYN. Phosphorylation leads to decreased mRNA-binding affinity, affecting transport and/or stabilization of MBP mRNA (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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