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Recombinant Mouse Anti-Rotavirus Group A Specific Antigen, VP6 Antibody (CB316) (CBMAB-MD322-LY)

The product is antibody recognizes Rotavirus. The antibody CB316 immunoassay techniques such as: ELISA.
See all Rotavirus Group A Specific Antigen, VP6 antibodies

Summary

Host Animal
Mouse
Specificity
Rotavirus
Clone
CB316
Antibody Isotype
IgG1
Application
ELISA

Basic Information

Immunogen
Human rotavirus purified by caesium chloride gradient.
Specificity
Rotavirus
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.5
Preservative
15 mM Sodium Azide
Purity
> 90% Purity determined by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Rotavirus Group A Specific Antigen, VP6
Function
Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices (PubMed:11285213).
This capsid constitutes the middle concentric layer of the viral mature particle (PubMed:11285213).
The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nascent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes (By similarity).
VP6 is required for the transcription activity of the DLP (PubMed:12097594).
Biological Process
Fusion of virus membrane with host plasma membrane
Cellular Location
Virion
Component of the intermediate capsid (PubMed:11285213).
Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging (Potential)
PTM
The N-terminus is blocked.
Sumoylated with SUMO1 and SUMO2. Sumoylation of viral proteins seems to have a positive role on viral replication.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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