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Rabbit Anti-RP2 Recombinant Antibody (EPR11362) (CBMAB-1781-CN)

This product is a rabbit antibody that recognizes RP2 of human. The antibody EPR11362 can be used for immunoassay techniques such as: FC, WB.
See all RP2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EPR11362
Antibody Isotype
IgG
Application
FC, WB

Basic Information

Immunogen
Synthetic peptide within Human RP2 aa. 300 to the C-terminus (Cysteine residue).
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
RP2, ARL3 GTPase Activating Protein
Introduction
The RP2 locus has been implicated as one cause of X-linked retinitis pigmentosa. The predicted gene product shows homology with human cofactor C, a protein involved in the ultimate step of beta-tubulin folding. This protein acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane. Involved in localization of proteins, such as NPHP3, to the cilium membrane by inducing hydrolysis of GTP ARL3, leading to the release of UNC119 (or UNC119B).
Entrez Gene ID
Human6102
Mouse19889
Rat367714
UniProt ID
HumanO75695
MouseQ9EPK2
RatD3ZTJ0
Alternative Names
XRP2; NME10; TBCCD2; NM23-H10; DELXp11.3
Function
Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane. Involved in localization of proteins, such as NPHP3, to the cilium membrane by inducing hydrolysis of GTP ARL3, leading to the release of UNC119 (or UNC119B). Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. Acts as guanine nucleotide dissociation inhibitor towards ADP-ribosylation factor-like proteins.
Biological Process
Biological Process cilium assemblyTAS:Reactome
Biological Process post-Golgi vesicle-mediated transportManual Assertion Based On ExperimentIMP:MGI
Biological Process protein foldingManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process protein transportIEA:UniProtKB-KW
Biological Process visual perceptionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cell membrane
Cell projection, cilium
Detected predominantly at the plasma membrane of rod and cone photoreceptors. Not detected in the nucleus.
Involvement in disease
Retinitis pigmentosa 2 (RP2):
A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
PTM
Myristoylated on Gly-2; which may be required for membrane targeting.
Palmitoylated on Cys-3; which may be required for plasma membrane targeting (Probable). Mutation of Cys-3 targets the protein to internal membranes.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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