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Mouse Anti-SARS-CoV 7a Recombinant Antibody (U122) (CBMAB-V208-0730-WJ)

This product is mouse antibody that recognizes SARS-CoV 7a. The antibody U122 can be used for immunoassay techniques such as: IF, WB.
See all SARS-CoV 7a antibodies

Summary

Host Animal
Mouse
Specificity
SARS
Clone
U122
Antibody Isotype
IgG
Application
IF, WB

Basic Information

Specificity
SARS
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SARS coronavirus 7a Protein
Introduction
The SARS coronavirus, sometimes shortened to SARS-CoV, is the virus that causes severe acute respiratory syndrome (SARS). SARS coronavirus is a positive and single stranded RNA virus belonging to a family of enveloped coronaviruses. Its genome is about 29.7kb, which is one of the largest among RNA viruses. The SARS virus has 13 known genes and 14 known proteins. There are 265 nucleotides in the 5'UTR and 342 nucleotides in the 3'UTR. SARS is similar to other coronaviruses in that its genome expression starts with translation of two large ORFs, 1a and 1b, both of which are polyproteins.
Alternative Names
SARS-CoV 7a; SARS coronavirus Protein 7a
Function
Plays a role as antagonist of host tetherin (BST2), disrupting its antiviral effect. Acts by binding to BST2 thereby interfering with its glycosylation. May suppress small interfering RNA (siRNA). May bind to host ITGAL, thereby playing a role in attachment or modulation of leukocytes.
Biological Process
Biological Process induction by virus of host apoptotic processManual Assertion Based On ExperimentIDA:DIBU
Biological Process modulation by virus of host G0/G1 transition checkpointIEA:UniProtKB-KW
Biological Process suppression by virus of host tetherin activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process suppression by virus of host type I interferon-mediated signaling pathwayIEA:UniProtKB-KW
Cellular Location
Virion
Host endoplasmic reticulum membrane
Host endoplasmic reticulum-Golgi intermediate compartment membrane
Host Golgi apparatus membrane
Topology
Virion surface: 16-96
Helical: 97-117
Intravirion: 118-122
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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