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Mouse Anti-SARS-CoV-E Recombinant Antibody (CB8) (CBMAB-V208-012LY)

The product is antibody recognizes SARS-CoV-E. The antibody CB8 immunoassay techniques such as: ELISA, WB.
See all SARS-CoV-E antibodies

Summary

Host Animal
Mouse
Specificity
SARS Coronavirus
Clone
CB8
Antibody Isotype
IgG2
Application
ELISA, WB

Basic Information

Immunogen
SARS-CoV envelope protein
Specificity
SARS Coronavirus
Antibody Isotype
IgG2
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
SARS-CoV envelope protein
Function
Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis (By similarity).
Activates the host NLRP3 inflammasome, leading to IL-1beta overproduction.
Biological Process
Biological Process disruption by virus of host cell membraneManual Assertion Based On ExperimentIDA:CACAO
Biological Process pore formation by virus in membrane of host cellIEA:InterPro
Biological Process viral budding from Golgi membraneManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Host endoplasmic reticulum-Golgi intermediate compartment
Host Golgi apparatus membrane
Colocalizes with S in the host endoplasmic reticulum-Golgi intermediate compartment (PubMed:20861307).
The cytoplasmic tail functions as a Golgi complex-targeting signal.
Topology
Virion surface: 1-16
Helical: 17-37
Intravirion: 38-76
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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