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Mouse Anti-SARS-CoV E2 Recombinant Antibody (AC04) (CBMAB-V208-0437-WJ)

This product is mouse antibody that recognizes SARS-CoV E2. The antibody AC04 can be used for immunoassay techniques such as: WB.
See all SARS-CoV E2 antibodies
Published Data

Summary

Host Animal
Mouse
Specificity
SARS
Clone
AC04
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Purified recombinant fragment of SARS-E2 glycoprotein precursor expressed in E. Coli
Specificity
SARS
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SARS coronavirus E2 glycoprotein precursor
Introduction
The SARS coronavirus, sometimes shortened to SARS-CoV, is the virus that causes severe acute respiratory syndrome (SARS). On April 16, 2003, following the outbreak of SARS in Asia and secondary cases elsewhere in the world, the World Health Organization (WHO) issued a press release stating that the coronavirus identified by a number of laboratories was the official cause of SARS. Samples of the virus are being held in laboratories in New York City, San Francisco, Manila, Hong Kong, and Toronto.
Alternative Names
E2; E2 glycoprotein precursor; SARS-CoV E2; SARS coronavirus
Function
Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis (By similarity).
Activates the host NLRP3 inflammasome, leading to IL-1beta overproduction.
Biological Process
Biological Process disruption by virus of host cell membraneManual Assertion Based On ExperimentIDA:CACAO
Biological Process pore formation by virus in membrane of host cellIEA:InterPro
Biological Process viral budding from Golgi membraneManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Host endoplasmic reticulum-Golgi intermediate compartment
Host Golgi apparatus membrane
Colocalizes with S in the host endoplasmic reticulum-Golgi intermediate compartment (PubMed:20861307).
The cytoplasmic tail functions as a Golgi complex-targeting signal.
Topology
Virion surface: 1-16
Helical: 17-37
Intravirion: 38-76
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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