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Mouse Anti-SDCCAG8 Recombinant Antibody (CBXS-4643) (CBMAB-S1882-CQ)

This product is a mouse antibody that recognizes SDCCAG8. The antibody CBXS-4643 can be used for immunoassay techniques such as: ELISA, WB, IHC.
See all SDCCAG8 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4643
Antibody Isotype
IgG2b
Application
ELISA, WB, IHC

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Serologically Defined Colon Cancer Antigen 8
Introduction
This gene encodes a centrosome associated protein. This protein may be involved in organizing the centrosome during interphase and mitosis. Mutations in this gene are associated with retinal-renal ciliopathy.
Entrez Gene ID
10806
UniProt ID
Q86SQ7
Alternative Names
Serologically Defined Colon Cancer Antigen 8; Centrosomal Colon Cancer Autoantigen Protein; Bardet-Biedl Syndrome 16; Nephrocystin 10; Antigen NY-CO-8; NPHP10; HCCCAP; CCCAP;
Function
Plays a role in the establishment of cell polarity and epithelial lumen formation (By similarity).
Also plays an essential role in ciliogenesis and subsequent Hedgehog signaling pathway that requires the presence of intact primary cilia for pathway activation. Mechanistically, interacts with and mediates RABEP2 centrosomal localization which is critical for ciliogenesis (PubMed:27224062).
Biological Process
Biological Process cell projection organizationIEA:UniProtKB-KW
Biological Process centrosome cycleIEA:InterPro
Biological Process establishment of cell polarityISS:UniProtKB
Biological Process microtubule organizing center organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process neuron migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of cilium assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process tube formationISS:UniProtKB
Cellular Location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Cytoplasm, cytoskeleton, cilium basal body
Cell junction
Located at the distal ends of both centrioles and colocalizes to centrosomes throughout the cell cycle.
Isoform 2
Cytoplasm
Involvement in disease
Senior-Loken syndrome 7 (SLSN7):
A renal-retinal disorder characterized by progressive wasting of the filtering unit of the kidney (nephronophthisis), with or without medullary cystic renal disease, and progressive eye disease. Typically this disorder becomes apparent during the first year of life.
Bardet-Biedl syndrome 16 (BBS16):
A syndrome characterized by usually severe pigmentary retinopathy, early-onset obesity, polydactyly, hypogenitalism, renal malformation and intellectual disability. Secondary features include diabetes mellitus, hypertension and congenital heart disease. Bardet-Biedl syndrome inheritance is autosomal recessive, but three mutated alleles (two at one locus, and a third at a second locus) may be required for clinical manifestation of some forms of the disease.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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