Sign in or Register   Sign in or Register
  |  

Mouse Anti-SRSF3 Recombinant Antibody (2D2) (CBMAB-A8035-LY)

The product is antibody recognizes SFRS3. The antibody 2D2 immunoassay techniques such as: WB, ELISA.
See all SRSF3 antibodies
Published Data
Fig.1 The HMGN3 RNA had no change in MDA-MB-231 and BT-20, but showed upregulation in others.
...View More
Fig.2 Expression of SRSF3 in oral epithelial dysplasia and cancers. Expression of SRSF3 was analyzed with immunohistochemistry in normal (A), mild dysplasia
(B), severe dysplasia (C), grade I OSCC (D), grade I-II OSCC (E), or grade II-III OSCC tissues (F). (A-F: magnification ×40).
...View More
Fig.3 Identification of exonic variants that influence inclusion of alternative U2AF1 exons.
...View More

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
2D2
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
SFRS3 (NP_003008, 1 a.a. ~ 85 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
serine and arginine rich splicing factor 3
Entrez Gene ID
Human6428
Mouse20383
Rat361814
UniProt ID
HumanP84103
MouseP84104
RatQ9JKL7
Alternative Names
SRp20
Function
Splicing factor that specifically promotes exon-inclusion during alternative splicing (PubMed:26876937).
Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937).
Also functions as export adapter involved in mRNA nuclear export (PubMed:11336712, PubMed:18364396, PubMed:28984244).
Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity (PubMed:11336712, PubMed:18364396).
Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244).
RNA-binding is semi-sequence specific (PubMed:17036044).
Biological Process
Biological Process cellular response to leukemia inhibitory factorIEA:Ensembl
Biological Process mRNA export from nucleusManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIBA:GO_Central
Biological Process primary miRNA processingManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process regulation of mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus
Nucleus speckle
Cytoplasm
Recruited to nuclear speckles following interaction with YTHDC1.
PTM
Phosphorylated by CLK1, CLK2, CLK3 and CLK4. Extensively phosphorylated on serine residues in the RS domain.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-SRSF3 Recombinant Antibody (2D2)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare