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Mouse Anti-SRRM4 Recombinant Antibody (IHC413) (CBMAB-MA234-YC)

Provided herein is a Mouse monoclonal antibody against Serine / Arginine Repetitive Matrix 4. The antibody can be used for immunoassay techniques, such as IHC. And it gave a positive signal in Cerebellum.
See all SRRM4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
IHC413
Application
IHC (1:100 - 1:200)

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
Tris buffer pH 7.3 - 7.7, 1% BSA, < 0.1% Sodium Azide
Storage
Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

Target

Full Name
Serine / Arginine Repetitive Matrix 4
Introduction
SRRM4 promotes alternative splicing and inclusion of neural-specific exons in target mRNAs.
Entrez Gene ID
84530
UniProt ID
A7MD48
Alternative Names
Serine/Arginine Repetitive Matrix 4; Neural-Specific SR-Related Protein Of 100 KDa; KIAA1853; Neural-Specific Serine/Arginine Repetitive Splicing Factor Of 100 KDa; Medulloblastoma Antigen MU-MB-2.76; NSR100; Serine/Arginine Repetitive Matrix Protein 4; MU-MB-2.76;
Function
Splicing factor specifically required for neural cell differentiation. Acts in conjunction with nPTB/PTBP2 by binding directly to its regulated target transcripts and promotes neural-specific exon inclusion in many genes that function in neural cell differentiation. Required to promote the inclusion of neural-specific exon 10 in nPTB/PTBP2, leading to increased expression of neural-specific nPTB/PTBP2. Also promotes the inclusion of exon 16 in DAAM1 in neuron extracts (By similarity).
Promotes alternative splicing of REST transcripts to produce REST isoform 3 (REST4) with greatly reduced repressive activity, thereby activating expression of REST targets in neural cells (PubMed:30684677).
Plays an important role during embryonic development as well as in the proper functioning of the adult nervous system. Regulates alternative splicing events in genes with important neuronal functions (By similarity).
Biological Process
Biological Process cell differentiationISS:UniProtKB
Biological Process mRNA processingISS:UniProtKB
Biological Process nervous system developmentISS:UniProtKB
Biological Process neuron maturationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of alternative mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of RNA splicingISS:UniProtKB
Biological Process RNA splicingIEA:UniProtKB-KW
Biological Process sensory perception of soundIEA:Ensembl
Cellular Location
Nucleus
PTM
Phosphorylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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