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Rabbit Anti-STOM Monoclonal Antibody (EPR10421) (CBMAB-1569-YC)

Provided herein is a rabbit monoclonal antibody against Human STOM. The antibody, clone EPR10421, can be used for immunoassay techniques, such as ICC, IF, IP, FC and WB.
See all STOM antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EPR10421
Antibody Isotype
IgG
Application
ICC, IF, IP, FC, WB

Basic Information

Immunogen
Synthetic peptide corresponding to residues in Human STOM (P27105).
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Stomatin
Introduction
STOM is a member of a highly conserved family of integral membrane proteins which localizes to the cell membrane of red blood cells and other cell types, where it may regulate ion channels and transporters. Loss of localization of the STOM is associated with hereditary stomatocytosis, a form of hemolytic anemia.
Entrez Gene ID
Human2040
Mouse13830
Rat296655
UniProt ID
HumanP27105
MouseP54116
RatQ5XI04
Alternative Names
BND7; EPB7; EPB72
Function
Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity.
Biological Process
Biological Process positive regulation by host of viral genome replicationIEA:Ensembl
Biological Process positive regulation of protein targeting to membraneIEA:Ensembl
Biological Process positive regulation of viral processIEA:Ensembl
Biological Process regulation of acid-sensing ion channel activityIEA:Ensembl
Cellular Location
Cell membrane
Cytoplasm, cytoskeleton
Cell membrane
Membrane raft
Melanosome
Cytoplasmic vesicle
Localizes to juxtanuclear structure probably derived from the Golgi apparatus (PubMed:9243190).
Colocalizes with cortical actin microfilaments at small plasma membrane protrusions (PubMed:9243190).
Associates with alpha-granular lipid rafts (PubMed:12130500).
Translocates from the alpha-granular lipid rafts to the cell membrane on thrombin activation and selectively enriched in released microvesicles (PubMed:12130500).
Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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