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Rabbit Anti-STX4 Monoclonal Antibody (EPR15473) (CBMAB-1613-YC)

Provided herein is a rabbit monoclonal antibody against Human STX4. The antibody, clone EPR15473, can be used for immunoassay techniques, such as WB.
See all STX4 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EPR15473
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Synthetic peptide within Human Syntaxin 4 aa 100-200.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
STX4
Introduction
STX4 is a protein that in humans is encoded by the STX4 gene.
Entrez Gene ID
Human6810
Mouse20909
Rat81803
UniProt ID
HumanQ12846
MouseP70452
RatQ08850
Alternative Names
STX4A; p35-2
Function
Plasma membrane t-SNARE that mediates docking of transport vesicles (By similarity).
Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane (By similarity).
In neurons, recruited at neurite tips to membrane domains rich in the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) which promotes neurite tip surface expression of the dopamine transporter SLC6A3/DAT by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane (By similarity).
Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes and in docking of synaptic vesicles at presynaptic active zones (By similarity).
Biological Process
Biological Process cellular response to interferon-gammaIEA:Ensembl
Biological Process cellular response to oxidative stressManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cornified envelope assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process exocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process long-term synaptic potentiationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process organelle fusionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of catalytic activityManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of cell adhesionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of cell population proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of chemotaxisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of eosinophil degranulationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of immunoglobulin productionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of insulin secretion involved in cellular response to glucose stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of protein localization to cell surfaceManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of protein localization to plasma membraneManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein localization to cell surfaceISS:UniProtKB
Biological Process regulation of exocytosisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of extrinsic apoptotic signaling pathway via death domain receptorsManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process SNARE complex assemblyIEA:Ensembl
Biological Process synaptic vesicle fusion to presynaptic active zone membraneManual Assertion Based On ExperimentIBA:GO_Central
Biological Process vesicle dockingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process vesicle fusionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell membrane
Cell projection, neuron projection
Localizes to neurite tips in neuronal cells.
Topology
Cytoplasmic: 1-275
Helical: 276-296
Extracellular: 297
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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