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Rabbit Anti-SUV39H2 Recombinant Antibody (CBLY1-178) (CBMAB-K2209-LY)

This product is antibody recognizes SUV39H2. The antibody CBLY1-178 immunoassay techniques such as: WB, IHC-P, IP.
See all SUV39H2 antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
CBLY1-178
Antibody Isotype
IgG
Application
WB, IHC-P, IP

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
suppressor of variegation 3-9 homolog 2
Entrez Gene ID
Human79723
Mouse64707
Rat364785
UniProt ID
HumanQ9H5I1
MouseQ9EQQ0
RatD3ZIH5
Function
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation.
Biological Process
Biological Process cell cycleIEA:UniProtKB-KW
Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process cellular response to hypoxiaManual Assertion Based On ExperimentIDA:MGI
Biological Process chromatin organizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process chromatin remodelingManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process histone H3-K9 dimethylationISS:UniProtKB
Biological Process histone H3-K9 trimethylationISS:UniProtKB
Biological Process histone lysine methylationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of circadian rhythmISS:UniProtKB
Biological Process negative regulation of DNA-templated transcriptionISS:UniProtKB
Biological Process negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:MGI
Biological Process rhythmic processIEA:UniProtKB-KW
Cellular Location
Nucleus
Chromosome, centromere
Associates with centromeric constitutive heterochromatin.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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