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Rabbit Anti-TMPRSS3 Monoclonal Antibody (EPR7048) (CBMAB-1647-YC)

Provided herein is a rabbit monoclonal antibody against Human TMPRSS3. The antibody, clone EPR7048, can be used for immunoassay techniques, such as IHC-P, ICC, IF, FC and WB.
See all TMPRSS3 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Rat
Clone
EPR7048
Antibody Isotype
IgG
Application
IHC-P, ICC, IF, FC, WB

Basic Information

Immunogen
A synthetic peptide corresponding to extracellular C-terminal residues in Human TMPRSS3 was used as an immunogen.
Specificity
Human, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
transmembrane protease, serine 3
Introduction
TMPRSS3 belongs to the serine protease family that contains a serine protease domain, a transmembrane domain, an LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. TMPRSS3 was identified by its association with both congenital and childhood onset autosomal recessive deafness. TMPRSS3 is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph.
Entrez Gene ID
Human64699
Rat309665
UniProt ID
HumanP57727
RatD3ZY65
Alternative Names
DFNB8; DFNB10; ECHOS1; TADG12
Function
Probable serine protease that plays a role in hearing. Acts as a permissive factor for cochlear hair cell survival and activation at the onset of hearing and is required for saccular hair cell survival (By similarity).
Activates ENaC (in vitro).
Biological Process
Biological Process cellular sodium ion homeostasisSource:MGI1 Publication
Biological Process proteolysisSource:UniProtKB1 Publication
Biological Process sensory perception of soundSource:Ensembl
Cellular Location
Endoplasmic reticulum membrane
Involvement in disease
Deafness, autosomal recessive, 8 (DFNB8):
A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Topology
Cytoplasmic: 1-48
Helical: 49-69
Extracellular: 70-454
PTM
Undergoes autoproteolytic activation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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