Sign in or Register   Sign in or Register
  |  

Mouse Anti-TMPRSS6 Recombinant Antibody (CBFYM-3162) (CBMAB-M3359-FY)

This product is mouse antibody that recognizes TMPRSS6. The antibody CBFYM-3162 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all TMPRSS6 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-3162
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TMPRSS6 GENE(PROTEIN CODING) TRANSMEMBRANE PROTEASE, SERINE 6
Introduction
The protein encoded by this gene is a type II transmembrane serine proteinase that is found attached to the cell surface. The encoded protein may be involved in matrix remodeling processes in the liver. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
164656
UniProt ID
Q8IU80
Alternative Names
Transmembrane Protease, Serine 6; Matriptase-2; Membrane-Bound Mosaic Serine Proteinase Matriptase-2; Type II Transmembrane Serine Protease 6; Transmembrane Protease Serine 6; EC 3.4.21.-; EC 3.4.21; IRIDA
Function
Membrane-bound serine protease (PubMed:18976966, PubMed:20518742, PubMed:25156943, PubMed:25588876).
Through the cleavage of cell surface HJV, a regulator of the expression of the iron absorption-regulating hormone hepicidin/HAMP, plays a role in iron homeostasis (PubMed:25156943, PubMed:18408718, PubMed:18976966).
Biological Process
Biological Process BMP signaling pathwaySource:Ensembl
Biological Process cellular iron ion homeostasisSource:BHF-UCL
Biological Process collagen catabolic processSource:Reactome
Biological Process extracellular matrix disassemblySource:Reactome
Biological Process iron ion homeostasisSource:UniProtKB1 Publication
Biological Process membrane protein proteolysisSource:UniProtKB1 Publication
Biological Process negative regulation of BMP signaling pathwaySource:Ensembl
Biological Process negative regulation of DNA-templated transcriptionSource:UniProtKB1 Publication
Biological Process negative regulation of transcription by RNA polymerase IISource:BHF-UCL
Biological Process positive regulation of transcription by RNA polymerase IISource:BHF-UCL
Biological Process self proteolysisSource:UniProtKB1 Publication
Cellular Location
Cell membrane
The processed, activated two-chains form is released in the extracellular space.
Involvement in disease
Iron-refractory iron deficiency anemia (IRIDA):
Key features include congenital hypochromic microcytic anemia, very low mean corpuscular erythrocyte volume, low transferrin saturation, abnormal iron absorption characterized by no hematologic improvement following treatment with oral iron, and abnormal iron utilization characterized by a sluggish, incomplete response to parenteral iron.
Topology
Cytoplasmic: 1-55
Helical: 56-76
Extracellular: 77-811
PTM
The single-chain zymogen undergoes autoproteolytic processing (PubMed:20518742, PubMed:25156943, PubMed:18976966).
This results in TMPRSS6 shedding from the cell surface and conversion into an activated two-chains form which is released extracellularly (PubMed:20518742, PubMed:25156943, PubMed:18976966).
The process involves a trans-activation mechanism that requires TMPRSS6 oligomerization (PubMed:20518742, PubMed:25156943).
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-TMPRSS6 Recombinant Antibody (CBFYM-3162)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare