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Mouse Anti-TRIB1 Recombinant Antibody (4A10) (CBMAB-A9491-LY)

The product is antibody recognizes TRIB1. The antibody 4A10 immunoassay techniques such as: WB, ELISA.
See all TRIB1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4A10
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
TRIB1 (NP_079471, 91 a.a. ~ 191 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
tribbles homolog 1 (Drosophila)
Entrez Gene ID
10221
UniProt ID
Q96RU8
Alternative Names
C8FW; GIG2; SKIP1
Function
Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase (PubMed:27041596).
The COP1-binding motif is masked by autoinhibitory interactions with the protein kinase domain (PubMed:26455797).
Serves to alter COP1 substrate specificity by directing the activity of COP1 toward CEBPA (PubMed:27041596).
Binds selectively the recognition sequence of CEBPA (PubMed:26455797).
Regulates myeloid cell differentiation by altering the expression of CEBPA in a COP1-dependent manner (By similarity).
Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity).
Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity (PubMed:15299019, PubMed:26455797).
Biological Process
Biological Process JNK cascade Source:BHF-UCL1 Publication
Biological Process negative regulation of DNA-binding transcription factor activity Source:BHF-UCL1 Publication
Biological Process negative regulation of lipopolysaccharide-mediated signaling pathway Source:BHF-UCL1 Publication
Biological Process negative regulation of neutrophil differentiation Source:Ensembl
Biological Process negative regulation of protein kinase activity Source:BHF-UCL1 Publication
Biological Process negative regulation of smooth muscle cell migration Source:BHF-UCL1 Publication
Biological Process negative regulation of smooth muscle cell proliferation Source:BHF-UCL1 Publication
Biological Process positive regulation of eosinophil differentiation Source:Ensembl
Biological Process positive regulation of macrophage differentiation Source:Ensembl
Biological Process positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source:BHF-UCLBy Similarity
Biological Process regulation of MAP kinase activity Source:UniProtKB1 Publication
Biological Process response to lipopolysaccharide Source:BHF-UCL1 Publication
Cellular Location
cytoplasm
cytosol
nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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