Synthetic peptide corresponding to the human Ku-70 around the acetylation site of K542
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus.
X-Ray Repair Cross Complementing 6; X-Ray Repair Complementing Defective Repair In Chinese Hamster Cells 6; Thyroid Autoantigen 70kDa (Ku Antigen); ATP-Dependent DNA Helicase 2 Subunit 1