This gene encodes an ATP-dependent DNA helicase that functions in nucleotide excision repair. The encoded protein is a subunit of basal transcription factor 2 (TFIIH) and, therefore, also functions in class II transcription. Mutations in this gene are associated with Xeroderma pigmentosum B, Cockayne's syndrome, and trichothiodystrophy. Alternative splicing results in multiple transcript variants.
ERCC Excision Repair 3, TFIIH Core Complex Helicase Subunit; Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 3; TFIIH Basal Transcription Factor Complex 89 KDa Subunit; Xeroderma Pigmentosum Group B-Complementing Protei