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Human FADD Peptide (RVDDFEAGAAAGAAPG) (PEP-021143CQ)

This product is synthetic peptide that is derived from Human FADD (AA 78-93). This peptide sequence corresponds to amino acid residues: RVDDFEAGAAAGAAPG.
Specificity
Human
Format
Lyophilized powder
Storage
Store at -20°C
Introduction
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
Alternative Name
Fas Associated Via Death Domain; Fas-Associating Death Domain-Containing Protein; Growth-Inhibiting Gene 3 Protein; Fas-Associating Protein With Death Domain; Fas (TNFRSF6)-Associated Via Death Domain; Mediator Of Receptor-Induced Toxicity
Entrez Gene ID
UniProt ID
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For Research Use Only. Not For Clinical Use.
Cat PEP-021143CQ
Conjugates
Size
Price $
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Second antibody and isotype control