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Creative Biolabs has successfully developed SARS, MERS and other anti-viral antibodies in the past to assist scientific research. Facing the difficult COVID-19, Creative Biolabs actively invests in antibody development to assist researchers to better understand the characteristics of 2019-nCoV and drug development. Currently, Creative Biolabs is proud to offer an extensive line of research antibodies to support the study of SARS-CoV-2/COVID-19, several of which were validated using virus-infected cell lysates.

Explore the collections of SARS-CoV-2/COVID-19 antibodies >

Human FBXW7 Peptide (GELKSPKVL) (PEP-022074CQ)

This product is synthetic peptide that is derived from Human FBXW7 (AA 368-376). This peptide sequence corresponds to amino acid residues: GELKSPKVL.
Specificity
Human
Format
Lyophilized powder
Storage
Store at -20°C
Introduction
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene.
Alternative Name
F-Box And WD Repeat Domain Containing 7; F-Box And WD Repeat Domain Containing 7, E3 Ubiquitin Protein Ligase; F-Box And WD-40 Domain Protein 7 (Archipelago Homolog, Drosophila); F-Box Protein FBX30; SEL-10; Fbx30; SEL10; HCdc4; FBW7; HAgo; F-Box And WD-40 Domain-Containing Protein 7; F-Box/WD Repeat-Containing Protein 7
Entrez Gene ID
UniProt ID
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Cat PEP-022074CQ
Conjugates
Size
Price $
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Second antibody and isotype control