Human Recombinant IGSF3 protein, His Tag (V2LY-0526-LY4695)

Name: Human Recombinant IGSF3 protein, His Tag
SKU: V2LY-0526-LY4695
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant IGSF3 protein, His Tag consist of Amino Acid: 1-1124 and predicts a molecular mass of 126.6 kDa.

Molecule Mass

126.6 kDa

Sequence

Amino Acid: 1-1124

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>98% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

immunoglobulin superfamily, member 3

Function

Lacrimal gland development Source: UniProtKB

Cellular Location

Membrane

Involvement in disease

Lacrimal duct defect (LCDD):
A condition resulting in the imbalance between tear production and tear drainage. Infants typically manifest persistent epiphora and/or recurrent infections of the lacrimal pathway, such as conjunctivitis. LCDD is caused by failure of the nasolacrimal duct to open into the inferior meatus.

Topology

Extracellular: 20-1124
Helical: 1125-1145
Cytoplasmic: 1146-1194

Curry, R. N., Aiba, I., Meyer, J., Lozzi, B., Ko, Y., McDonald, M. F., ... & Deneen, B. (2023). Glioma epileptiform activity and progression are driven by IGSF3-mediated potassium dysregulation. Neuron, 111(5), 682-695.

Venkataramani, V. (2023). IGSF3-mediated potassium dysregulation promotes neuronal hyperexcitability and glioma progression. Trends in Cancer.

Schweitzer, K., Egersdorf, N., Rivera, T., DuBois, B., Cornell, C., Borowiec, A., ... & Petrache, I. (2023). IGSF3 (immunoglobulin superfamily 3) and glycosphingolipids associated with lung cell proliferation during recovery from respiratory SARS-CoV-2 infection. Physiology, 38(S1), 5795558.

Peng, W., Xie, Y., Xia, J., Li, B., Zhang, F., Wen, F., ... & Zhang, L. (2022). Association of Circulating Biomarkers of lnc-IGSF3-1: 1, SCOC-AS1, and SLC8A1-AS1 with Salt Sensitivity of Blood Pressure in Chinese Population. Journal of Cardiovascular Translational Research, 15(4), 906-917.

Schweitzer, K., Nall, J., Foster, D., Ashner, Y., Sajuthi, S., Correll, K., ... & Petrache, I. (2021). Upregulation of IGSF3 expression by iron chelation leads to the inhibition of epithelial cell proliferation. The FASEB Journal, 35.

Sheng, P., Zhu, H., Zhang, W., Xu, Y., Peng, W., Sun, J., ... & Jiang, H. (2020). The immunoglobulin superfamily member 3 (igsf3) promotes hepatocellular carcinoma progression through activation of the nf-κb pathway. Annals of Translational Medicine, 8(6).

Schweitzer, K. S., Jinawath, N., Yonescu, R., Ni, K., Rush, N., Charoensawan, V., ... & Petrache, I. (2020). IGSF3 mutation identified in patient with severe COPD alters cell function and motility. JCI insight, 5(14).

Wang, F., Tao, H., Han, C., Bai, F., Wang, P., Zhou, X. B., ... & Liu, C. (2020). Preliminary report on screening IGSF3 gene mutation in families with congenital absence of lacrimal puncta and canaliculi. International Journal of Ophthalmology, 13(9), 1351.

Schweitzer, K., & Petrache, I. (2019). Role of IGSF3 in Lung Epithelial Barrier Disruption Induced by Cigarette Smoke Exposure. The FASEB Journal, 33(S1), 655-8.

Schweitzer, K., Ni, K., Jacobson, S., Bronova, I., Berdyshev, E., Bowler, R., & Petrache, I. (2018). The Role of IGSF3 in Cell Adhesion, Proliferation, and Cell Migration. Annals of the American Thoracic Society, 15(Supplement 4), S291-S291.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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