Human Recombinant RIOK3 protein, GST Tag (V2LY-0526-LY6550)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling (PubMed:25865883).
Can inhibit CASP10 isoform 7-mediated activation of the NF-kappaB signaling pathway (PubMed:19557502).
May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of 21S pre-rRNA to the mature 18S rRNA (PubMed:22418843).
Biological Process cellular response to dsRNAManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cellular response to virusManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process chromosome segregationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process defense response to virusIEA:UniProtKB-KW
Biological Process innate immune responseIEA:UniProtKB-KW
Biological Process maturation of SSU-rRNAManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of MDA-5 signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of protein-containing complex assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of innate immune responseManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of interferon-beta productionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein phosphorylationIEA:InterPro
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
Alternative Versions
RIOK3 Matched Antibody Pair (996) (CAT#: APMAB-996LY)
Antibody Pairs
RIOK3 Matched Antibody Pair (996) (CAT#: APMAB-996LY)
Related Products
RIOK3 Matched Antibody Pair (996) (CAT#: APMAB-996LY)
RIOK3 Matched Antibody Pair (997) (CAT#: APMAB-997LY)
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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