Human IDH1 Peptide (AEAAHGTVT) (PEP-029893CQ)

This product is synthetic peptide that is derived from Human IDH1 (AA 305-313). This peptide sequence corresponds to amino acid residues: AEAAHGTVT.
Lyophilized powder
Store at -20°C
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
Alternative Name
Isocitrate Dehydrogenase (NADP(+)) 1, Cytosolic; HEL-216; HEL-S-26; IDCD; IDH; IDP; IDPC; PICD
Entrez Gene ID
UniProt ID
Cat PEP-029893CQ